Expression of vascular endothelial growth factor (VEGF) under hypoxia in placenta with intrahepatic cholestasis of pregnancy and its clinically pathological significance.

Abstract

UNLABELLED:

The expression of vascular endothelial growth factor (VEGF) under hypoxia in the placenta with intrahepatic cholestasis of pregnancy (ICP) was observed, and mechanisms of ICP fetal distress were discussed.

METHODS:

Different culturing times were established in hypoxia incubator, and protein expressions of VEGF in placental tissue were observed using immunohistochemical S-P method.

RESULTS:

After 4 h hypoxic culture, VEGF protein expression in ICP group was higher than the normal group with significant difference (P < 0.05). With the extension of hypoxic exposure, VEGF protein expression in both groups was suppressed, but no distinction in-between. Regression analyses indicated a noticeable effect of CG on VEGF expression, the higher the CG was, the lower the VEGF protein expression was (P < 0.05).

CONCLUSIONS:

Short term hypoxia induces up-regulation of VEGF expression in ICP placenta, and this adaptive change is probably a protective mechanism of fetus in ICP.

• Authors: Rong Zhang, Xiao-Hong Pan, Li Xiao
• Journal: International journal of clinical and experimental pathology (Int J Clin Exp Pathol) Vol. 8 Issue 9 Pg. 11475-9 ( 2015) ISSN: 1936-2625 [Electronic] United States
• PMID: 26617878 (Publication Type: Journal Article)

Chemical References

• VEGFA protein, human
• Vascular Endothelial Growth Factor A

Topics

• Adult
• Cholestasis, Intrahepatic (metabolism)
• Female
• Humans
• Hypoxia (metabolism)
• Immunohistochemistry
• In Vitro Techniques
• Infant, Newborn
• Placenta (metabolism)
• Pregnancy
• Pregnancy Complications (metabolism)
• Vascular Endothelial Growth Factor A (metabolism)