Abstract | PURPOSE: METHODS: RESULTS: The inflammation in the VCZ and liposomal Amp-B groups was milder than that in the control group. Corneal opacity, aqueous flare, and vitreous opacity scores, as well as electroretinographic recording, showed significantly less inflammation in the VCZ group compared with the liposomal Amp-B group during the early and middle stages of endophthalmitis (P < 0.05). Normal histologic structure of the retina was observed in eyes treated with VCZ and liposomal Amp-B. CONCLUSIONS: Both intravitreal VCZ and liposomal Amp-B were effective treatments for A. fumigatus-induced endophthalmitis in guinea pigs. Voriconazole was superior to liposomal Amp-B at doses similar to the initial therapy for acute infections. Further experimental and clinical studies are required to confirm the efficacy of these two antifungal drugs. Chinese Abstract.
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Authors | Jinsong Zhao, Yan Cheng, Xiande Song, Chenguang Wang, Guanfang Su, Zaoxia Liu |
Journal | Investigative ophthalmology & visual science
(Invest Ophthalmol Vis Sci)
Vol. 56
Issue 12
Pg. 7369-76
(Nov 2015)
ISSN: 1552-5783 [Electronic] United States |
PMID | 26574795
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antifungal Agents
- liposomal amphotericin B
- Amphotericin B
- Voriconazole
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Topics |
- Amphotericin B
(administration & dosage)
- Animals
- Antifungal Agents
(administration & dosage)
- Aspergillosis
(diagnosis, drug therapy, microbiology)
- Aspergillus fumigatus
(isolation & purification)
- Disease Models, Animal
- Electroretinography
- Endophthalmitis
(diagnosis, drug therapy, microbiology)
- Eye Infections, Fungal
(diagnosis, drug therapy, microbiology)
- Guinea Pigs
- Intravitreal Injections
- Voriconazole
(administration & dosage)
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