Is there any relation between PET-CT SUVmax value and prognostic factors in locally advanced breast cancer?

Abstract

PURPOSE:

To investigate the relation between PET-CT SUVmax value and prognostic factors in locally advanced breast cancer.

METHODS:

Data of 73 patients were retrospectively analyzed. Relations between SUVmax value, clinical stage, tumor grade and breast cancer molecular subtypes were analyzed by using one-way ANOVA and x(2) tests. Correlations between age, ki-67 scores and SUVmax were evaluated by using Pearson's correlation test. A p value <0.05 was considered statistically significant.

RESULTS:

Median SUVmax values for clinical stages 1, 2 and 3 were 5 (range 2.1-4.1), 10.6 (range 2.9-19.6), and 12.2 (range 3.2-23.3), respectively. Statistically significant difference was noticed between stage 1 and 2 (p=0.014) and stage 1 and 3 (p=0.001). Median SUVmax values of triple negative, luminal A, luminal B and non-luminal HER2 positive groups were 14.4 (range 6.6-23.3), 8.2 (range 2.1-18.2), 10.1 (range 3.5-19.6), and 14 (range 4.1-22.9), respectively. Statistically significant differences were noticed in SUVmax values between triple-negative and luminal A groups (p=0.005) and between non-luminal HER2 positive and luminal A groups (p=0.02). Median SUVmax values of grade 1, 2 and 3 were 5.7 (range 2.1-18.2), 9.5 (range 2.2-21.3), and 11.6 (range 3.5-23), respectively. Statistically significant difference was noticed only between SUVmax values of grade 1 and 3 (p=0.035). There was negative correlation between age and SUVmax value (r=-0.23, p=0.047) and positive correlation between ki-67 and SUVmax value (r=0.43, p=0.016).

CONCLUSION:

There were significant positive relations between PET-CT SUVmax value and clinical stage, tumor grade, and certain breast cancer molecular subtypes (triple-negative and non-luminal HER2 positive groups. Moreover, positive correlation was found between SUVmax value and ki-67 and negative correlation between SUVmax value and age.

• Authors: Deniz Tural, Derya Kivrak Salim, Hasan Mutlu, Metin Erkilic, Seyda Gunduz, Melek Karakurt, Fatma Musri, Savas Tuna, Adil Boz, Funda Aydin, Binnur Karayalcin, Hakan Bozcuk, Hasan Senol Coskun
• Journal: Journal of B.U.ON. : official journal of the Balkan Union of Oncology (J BUON) 2015 Sep-Oct Vol. 20 Issue 5 Pg. 1282-6 ISSN: 1107-0625 [Print] Cyprus
• PMID: 26537076 (Publication Type: Journal Article)

Chemical References

• Ki-67 Antigen
• ERBB2 protein, human
• Receptor, ErbB-2

Topics

• Adult
• Aged
• Breast Neoplasms (diagnostic imaging, pathology)
• Female
• Humans
• Ki-67 Antigen (analysis, chemistry)
• Middle Aged
• Positron-Emission Tomography
• Prognosis
• Receptor, ErbB-2 (analysis)
• Retrospective Studies
• Tomography, X-Ray Computed