Lymphocyte/monocyte ratio in osteoarticular tuberculosis in children: a haematological biomarker revisited.

Abstract

INTRODUCTION:

*Work attributed to Department of Pediatric Orthopaedics, Chacha Nehru Bal Chikitsalaya, Geeta Colony, Delhi-110031(India)This study tested the hypothesis whether the lymphocyte/monocyte ratio (L/M ratio) altered significantly during treatment of paediatric osteoarticular tuberculosis (OATB) for it to be a useful monitor of the response to therapy.

MATERIAL AND METHODS:

Thirty immunocompetent paediatric patients with OATB treated with 6 months of uninterrupted multidrug anti-tubercular treatment with resultant clinical and radiological healing of the lesion were included. Haemoglobin, total leucocyte, monocyte and lymphocyte count, and erythrocyte sedimentation rate (ESR) were collected at 0, 2 and 6 months, and were analysed.

RESULTS:

The L/M ratio altered from high (11) at the start of treatment towards normalisation (9) at 2 months and (7.7) at 6 months. There was no correlation with declining ESR levels.

CONCLUSIONS:

The L/M ratio may have potential as an effective biomarker response.

• Authors: Anil Agarwal, Mohd Shafi Bhat, Anubrat Kumar, Abbas Shaharyar, Madhusudhan Mishra, Rajeev Yadav
• Journal: Tropical doctor (Trop Doct) Vol. 46 Issue 2 Pg. 73-7 (Apr 2016) ISSN: 1758-1133 [Electronic] England
• PMID: 26503639 (Publication Type: Evaluation Study, Journal Article)
• Copyright: © The Author(s) 2015.

Chemical References

• Antitubercular Agents
• Biomarkers

Topics

• Adolescent
• Antitubercular Agents (therapeutic use)
• Biomarkers (blood)
• Child
• Child, Preschool
• Female
• Humans
• India
• Infant
• Lymphocytes (physiology)
• Male
• Monocytes (physiology)
• Predictive Value of Tests
• Retrospective Studies
• Tuberculosis, Osteoarticular (blood, diagnosis, drug therapy)