Abstract | OBJECTIVE: The aim of this study was to clarify the clinicopathologic factors of stages IB to IIB cervical adenocarcinoma. METHODS: RESULTS: In patients with adenocarcinoma, univariate analysis demonstrated that International Federation of Gynecology and Obstetrics stage, tumor size, and lymphovascular space invasion were significantly associated with progression-free survival (PFS), whereas FIGO stage, lymphovascular space invasion, and lymph node metastasis were significantly associated with overall survival (OS). However, multivariate analysis revealed that FIGO stage was the only significant factor for PFS in patients with adenocarcinoma. In patients with SCC, univariate analysis demonstrated that FIGO stage and lymph node metastasis were significantly associated with PFS, whereas FIGO stage, lymphovascular space invasion, and lymph node metastasis were significantly associated with OS. Multivariate analysis revealed that lymph node metastasis was the only significant factor for PFS and OS in patients with SCC. In 26 patients who were positive for high-risk human papillomavirus (HPV), including both adenocarcinoma and SCC patients, univariate and multivariate analyses revealed that HPV18 was significantly associated with poorer PFS compared with non-HPV18. There was a significant difference in distribution of HPV genotype between adenocarcinoma and SCC. CONCLUSIONS: Careful treatment may be necessary for the patients with lymphovascular space invasion in early-stage cervical adenocarcinoma. The presence of HPV18 may have an influence on the prognosis of early-stage cervical carcinoma.
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Authors | Yasushi Mabuchi, Tamaki Yahata, Aya Kobayashi, Yuko Tanizaki, Michihisa Shiro, Nami Ota, Shigetaka Yagi, Sawako Minami, Kazuhiko Ino |
Journal | International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
(Int J Gynecol Cancer)
Vol. 25
Issue 9
Pg. 1677-82
(Nov 2015)
ISSN: 1525-1438 [Electronic] England |
PMID | 26495760
(Publication Type: Journal Article)
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Topics |
- Adenocarcinoma
(complications, pathology, therapy)
- Adult
- Aged
- Blood Vessels
(pathology)
- Carcinoma, Squamous Cell
(complications, pathology, therapy)
- Chemotherapy, Adjuvant
- Disease-Free Survival
- Female
- Genotype
- Human papillomavirus 18
(genetics)
- Humans
- Hysterectomy
- Lymph Node Excision
- Lymphatic Metastasis
- Lymphatic Vessels
(pathology)
- Middle Aged
- Neoplasm Invasiveness
- Neoplasm Staging
- Papillomavirus Infections
(complications, virology)
- Radiotherapy, Adjuvant
- Survival Rate
- Tumor Burden
- Uterine Cervical Neoplasms
(complications, pathology, therapy)
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