Abstract | BACKGROUND: Adequate antiplatelet therapy in patients with myocardial infarction with ST-elevation ( STEMI) is vital in order to avoid ischemic complications. However, especially with the novel potent oral drugs, bleeding is a major concern. We aimed to investigate whether STEMI patients switched to novel ADP receptor inhibitors due to high platelet reactivity (HPR) on clopidogrel have similar outcomes compared to patients with adequate response to clopidogrel. METHODS: A prospective cohort of 175 STEMI patients (mean age 62.3 years) undergoing primary PCI were included in the PASTOR study. Patients were loaded with 600 mg clopidogrel before the index PCI procedure. Bedside VerifyNow P2Y12 platelet function testing was performed the following morning. RESULTS: CONCLUSIONS: Following primary PCI for STEMI, patients with adequate response to clopidogrel show similar outcomes compared to patients switched to novel ADP receptor antagonists due to HPR on clopidogrel. Platelet reactivity testing can be used to guide the choice of antiplatelet therapy in patients with STEMI treated by primary PCI.
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Authors | Jussi Mikkelsson, Tuomas Paana, Aino Lepantalo, Pasi P Karjalainen |
Journal | International journal of cardiology
(Int J Cardiol)
Vol. 202
Pg. 463-6
(Jan 01 2016)
ISSN: 1874-1754 [Electronic] Netherlands |
PMID | 26436674
(Publication Type: Journal Article)
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Copyright | Copyright © 2015 Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
- Antithrombins
- Platelet Aggregation Inhibitors
- Purinergic P2Y Receptor Antagonists
- Clopidogrel
- Ticlopidine
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Topics |
- Aged
- Antithrombins
(administration & dosage)
- Clopidogrel
- Female
- Humans
- Male
- Middle Aged
- Myocardial Infarction
(blood, drug therapy, surgery, therapy)
- Percutaneous Coronary Intervention
(methods)
- Platelet Aggregation Inhibitors
(administration & dosage, adverse effects)
- Precision Medicine
(methods)
- Prospective Studies
- Purinergic P2Y Receptor Antagonists
(administration & dosage, adverse effects, therapeutic use)
- Ticlopidine
(administration & dosage, adverse effects, analogs & derivatives)
- Treatment Outcome
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