Nanoparticle Mediated Tumor Vascular Disruption: A Novel Strategy in Radiation Therapy.

Abstract

More than 50% of all cancer patients receive radiation therapy. The clinical delivery of curative radiation dose is strictly restricted by the proximal healthy tissues. We propose a dual-targeting strategy using vessel-targeted-radiosensitizing gold nanoparticles and conformal-image guided radiation therapy to specifically amplify damage in the tumor neoendothelium. The resulting tumor vascular disruption substantially improved the therapeutic outcome and subsidized the radiation/nanoparticle toxicity, extending its utility to intransigent or nonresectable tumors that barely respond to standard therapies.

• Authors: Sijumon Kunjachan, Alexandre Detappe, Rajiv Kumar, Thomas Ireland, Lisa Cameron, Douglas E Biancur, Vincent Motto-Ros, Lucie Sancey, Srinivas Sridhar, G Mike Makrigiorgos, Ross I Berbeco
• Journal: Nano letters (Nano Lett) Vol. 15 Issue 11 Pg. 7488-96 (Nov 11 2015) ISSN: 1530-6992 [Electronic] United States
• PMID: 26418302 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Retracted Publication)

Chemical References

• Gold

Topics

• Cell Line, Tumor
• Endothelium (drug effects, pathology, radiation effects)
• Gold (adverse effects, chemistry)
• Humans
• Metal Nanoparticles (administration & dosage, adverse effects)
• Neoplasms (drug therapy, pathology, radiotherapy)
• Neovascularization, Pathologic (drug therapy, pathology, radiotherapy)
• Radiation Tolerance (drug effects)
• Radiotherapy, Image-Guided