[Effects of fructose-1,6-diphosphate in patients with chronic ischemic heart disease. Echocardiographic study].

Abstract

The effects of fructose-1,6-diphosphate (FDP) on cardiac activity were studied in 20 patients with chronic ischemic heart disease. Each patient received intravenously, in two different days, a single dose of FDP 20 g and placebo, according to a cross-over study design. Immediately prior to and ten minutes following each dosing, patients underwent an echocardiographic assessment. The comparison of pre- and post-treatment readings indicates that the diasto-systolic difference of left ventricular dimension increased by 10% after FDP (p less than 0.01). Similarly the increment of interventricular septum thickness increased by 16% (p less than 0.01) and that of posterior left ventricular wall thickness by 19% (p less than 0.01). In contrast the changes recorded after placebo treatment were far from being significant. These data indicate that the acute administration of a single dose of FDP may improve the cardiac performance in patients with chronic ischemic heart disease.

• Authors: C Pasotti, S Nicrosini, G Fiori
• Journal: Rivista europea per le scienze mediche e farmacologiche = European review for medical and pharmacological sciences = Revue europeenne pour les sciences medicales et pharmacologiques (Riv Eur Sci Med Farmacol) Vol. 11 Issue 4 Pg. 315-20 (Aug 1989) ISSN: 0392-291X [Print] Italy
• Vernacular Title: Impiego del fruttosio-1,6-difosfato in pazienti con cardiopatia ischemica cronica. Studio ecocardiografico.
• PMID: 2640054 (Publication Type: Clinical Trial, Controlled Clinical Trial, English Abstract, Journal Article)

Chemical References

• Fructosediphosphates
• Hexosediphosphates
• fructose-1,6-diphosphate

Topics

• Adult
• Aged
• Chronic Disease
• Coronary Disease (drug therapy, physiopathology)
• Echocardiography
• Female
• Fructosediphosphates (therapeutic use)
• Hexosediphosphates (therapeutic use)
• Humans
• Male
• Middle Aged