Isolation and Characterization of an Unknown Chrysosporium sp. Producing Subcutaneous Mycosis in an Immunocompromised Patient.

Abstract

We report a case of subcutaneous fungal abscess over the great toe caused by a keratinophilic fungus, an unknown Chrysosporium sp., in a 60-year-old diabetic female who was treated successfully with oral fluconazole. The fungus was isolated from aspirated pus, and septate hyphae were seen in fine needle aspiration cytology. Ovoid- to club-shaped hyaline one-celled conidia (aleuriconidia) with broad truncated bases were seen, and sequencing of ITS1-5.8S-ITS2 rDNA revealed belonging to the order Onygenales and most closely related to Chrysosporium spp. isolated from a fowl. Of the 65 species within the genus Chrysosporium, very few have been reported as pathogenic.

• Authors: Sagar Chandrakar, Meena Dias, Prathvi Shetty, Jutang Babat Ain Tiewsoh, Josep Guarro
• Journal: Mycopathologia (Mycopathologia) Vol. 181 Issue 1-2 Pg. 115-8 (Feb 2016) ISSN: 1573-0832 [Electronic] Netherlands
• PMID: 26346376 (Publication Type: Journal Article)

Chemical References

• Antifungal Agents
• DNA, Fungal
• DNA, Ribosomal Spacer
• Fluconazole

Topics

• Abscess (etiology, microbiology, pathology)
• Antifungal Agents (administration & dosage)
• Biopsy, Fine-Needle
• Chrysosporium (classification, genetics, isolation & purification)
• DNA, Fungal (chemistry, genetics)
• DNA, Ribosomal Spacer (chemistry, genetics)
• Dermatomycoses (diagnosis, microbiology, pathology)
• Diabetes Complications
• Female
• Fluconazole (administration & dosage)
• Humans
• Immunocompromised Host
• Microbiological Techniques
• Middle Aged
• Molecular Sequence Data
• Sequence Analysis, DNA
• Treatment Outcome