Abstract | BACKGROUND: Mucous membrane pemphigoid ( MMP) and oral lichen planus (OLP) show similar clinical features on the oral mucosa. As clinical manifestations of oral mucosal lesions, MMP shows blisters and erosions, whereas OLP shows lace-like whitish lesions in an annular arrangement with erythema and erosions. Histopathologically, MMP shows subepithelial bullae with infiltrates of lymphocytes and neutrophils, whereas OLP shows band-like interface infiltration of lymphocytes with damage in basal cells. However, these two diseases are frequently difficult to distinguish both clinically and histopathologically. OBJECTIVES: We report four patients with oral MMP who showed OLP-like clinical and histopathological lesions. METHODS: We performed direct immunofluorescence, indirect immunofluorescence of normal human skin and 1 m NaCl-split skin, enzyme-linked immunosorbent assays for BP180, BP230, and desmogleins 1 and 3, and immunoblotting of normal human epidermal and dermal extracts, recombinant proteins of BP180-NC16a and -C-terminal domains, concentrated culture supernatant of HaCaT cells, and purified laminin-332. RESULTS: The results of various immunological studies suggested the diagnoses of various types of MMP for all four patients. CONCLUSIONS: Because MMP and OLP require different treatments, all dentists and dermatologists should have knowledge about the disease entity and the serological diagnostic methods for various types of MMP.
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Authors | Aoi Fukuda, Akio Himejima, Daisuke Tsuruta, Hiroshi Koga, Bungo Ohyama, Shosuke Morita, Takashi Hashimoto |
Journal | International journal of dermatology
(Int J Dermatol)
Vol. 55
Issue 6
Pg. 657-65
(Jun 2016)
ISSN: 1365-4632 [Electronic] England |
PMID | 26341508
(Publication Type: Case Reports, Journal Article)
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Copyright | © 2015 The International Society of Dermatology. |
Chemical References |
- Autoantibodies
- Autoantigens
- Cell Adhesion Molecules
- DST protein, human
- Desmoglein 1
- Desmoglein 3
- Dystonin
- Non-Fibrillar Collagens
- Recombinant Proteins
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Topics |
- Aged
- Autoantibodies
(analysis)
- Autoantigens
(analysis, genetics, immunology)
- Cell Adhesion Molecules
(immunology)
- Cell Line
- Desmoglein 1
(analysis, immunology)
- Desmoglein 3
(analysis, immunology)
- Diagnosis, Differential
- Dystonin
(analysis, immunology)
- Female
- Humans
- Lichen Planus, Oral
(diagnosis, immunology, pathology)
- Male
- Middle Aged
- Non-Fibrillar Collagens
(analysis, genetics, immunology)
- Pemphigoid, Benign Mucous Membrane
(diagnosis, immunology, pathology)
- Recombinant Proteins
(analysis)
- Skin
(chemistry)
- Kalinin
- Collagen Type XVII
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