rs4771122 Predicts Multiple Measures of Long-Term Weight Loss After Bariatric Surgery.

Abstract

We examined the association of 34 single nucleotide polymorphisms with weight loss up to 9.5 years after Roux-en-Y surgery. Participants were enrollees in the NUgene biobank with stored DNA and linked electronic health records. Ninety-five self-identified white participants underwent surgery and had follow-up weights obtained between 1 and 9.5 years after surgery. SNP rs4771122 was the variant most significantly associated with long-term weight loss after surgery in a repeated linear mixed model (p = .004) of long-term weight loss. In this model, each additional copy of the minor allele was associated with nearly 5 % greater percentage weight loss. This same SNP was also nominally significantly (p < .05) associated with weight loss trajectories, weight loss nadir, and weight loss 2 years after surgery.

• Authors: Laura J Rasmussen-Torvik, Abigail S Baldridge, Jennifer A Pacheco, Sharon A Aufox, Kwang-Youn A Kim, Jonathan C Silverstein, Erwin W Denham, Eric Hungness, Maureen E Smith, Philip Greenland
• Journal: Obesity surgery (Obes Surg) Vol. 25 Issue 11 Pg. 2225-9 (Nov 2015) ISSN: 1708-0428 [Electronic] United States
• PMID: 26337695 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• Eukaryotic Initiation Factors
• MTIF3 protein, human
• Mitochondrial Proteins

Topics

• Adult
• Bariatric Surgery
• Databases, Genetic
• Eukaryotic Initiation Factors (genetics)
• Female
• Humans
• Male
• Middle Aged
• Mitochondrial Proteins (genetics)
• Obesity, Morbid (genetics, surgery)
• Polymorphism, Single Nucleotide
• Weight Loss (genetics)