An integrated approach with vardenafil orodispersible tablet and cognitive behavioral sex therapy for treatment of erectile dysfunction: a randomized controlled pilot study.

Abstract

Erectile Dysfunction is considered a multifactorial disease, where organic and psychological aspects are often interconnected. In a randomized controlled pilot study, we compared the efficacy of combined vardenafil orodispersible tablet (VARD) and cognitive-behavioral sex therapy (CBST) vs. VARD alone in improving sexual symptoms in both male and female partners. Thirty male patients with erectile dysfunction, and their partners were randomly assigned with a 2 : 1 ratio, to two different arms and treated for 10 weeks with VARD (Group A; n = 19) or VARD+CBST (Group B; n = 11). International Index of Erectile Dysfunction (IIEF-15), Female Sexual Function Index (FSFI) and Index of Sexual Satisfaction (ISS) were, respectively, administered to male, female, and both partners at times (T) 0, 1 (+5 weeks of therapy) and 2 (+10 weeks of therapy). Groups A and B were similar in their sociodemographic and clinical characteristics. Pre-treatment (T0) test scores did not significantly differ among the groups. In both group A and B, the IIEF-Erectile Function domain showed a significant improvement from T0 to T1 (p = 0.005 and p < 0.0001 vs. T0, respectively) and from T0 to T2 only in group B (p = 0.013). In group A, FSFI and both male and female ISS did not show any significant change at T1 and T2 vs. T0. In group B, a significant improvement at final time-point in FSFI and male and female ISS scores was reported (p < 0.05, T2 vs. T0 in all scores). The results of our study suggest that both VARD alone and VARD+CBST improved erectile function, however, only VARD+CBST improved couple sexual satisfaction and female sexual function.

• Authors: V Boddi, G Castellini, H Casale, G Rastrelli, L Boni, G Corona, M Maggi
• Journal: Andrology (Andrology) Vol. 3 Issue 5 Pg. 909-18 (Sep 2015) ISSN: 2047-2927 [Electronic] England
• PMID: 26311340 (Publication Type: Journal Article, Randomized Controlled Trial)
• Copyright: © 2015 American Society of Andrology and European Academy of Andrology.

Chemical References

• Vardenafil Dihydrochloride

Topics

• Adult
• Cognitive Behavioral Therapy (methods)
• Coitus (physiology)
• Erectile Dysfunction (therapy)
• Female
• Humans
• Male
• Middle Aged
• Patient Satisfaction
• Penile Erection (drug effects, psychology)
• Pilot Projects
• Self Report
• Sexual Behavior (psychology)
• Surveys and Questionnaires
• Treatment Outcome
• Vardenafil Dihydrochloride (therapeutic use)