Stable and compact zwitterionic polydiacetylene micelles with tumor-targeting properties.

Abstract

Compact polymerized polydiacetylene-micelles with "stealth" zwitterionic surface coating were assembled and tested in a murine xenograft model of breast cancer. In vivo fluorescence imaging indicated accumulation in the tumor area and histological studies revealed predominant uptake of the micelles at the margins of the tumor, thereby allowing the delineation of its volume.

• Authors: Ioanna Theodorou, Parambath Anilkumar, Benoit Lelandais, Damien Clarisse, Anaëlle Doerflinger, Edmond Gravel, Frédéric Ducongé, Eric Doris
• Journal: Chemical communications (Cambridge, England) (Chem Commun (Camb)) Vol. 51 Issue 80 Pg. 14937-40 (Oct 14 2015) ISSN: 1364-548X [Electronic] England
• PMID: 26307176 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Micelles
• Polyacetylene Polymer
• Polymers
• Polyynes
• polydiacetylene

Topics

• Animals
• Breast Neoplasms (drug therapy)
• Female
• Heterografts
• Mice
• Micelles
• Polyacetylene Polymer
• Polymers (chemistry, therapeutic use)
• Polyynes (chemistry, therapeutic use)