Abstract |
KU80 is well-known as a key component of the non-homologous end-joining pathway used to repair DNA double-strand breaks. In addition, the KU80-containing DNA-dependent protein kinase complex in mammals can act as a cytoplasmic sensor for viral DNA to activate innate immune response. We have now, to our knowledge for the first time, demonstrated that the speed of a systemic infection with a plant DNA geminivirus in Arabidopsis thaliana is KU80-dependent. The early emergence of Euphorbia yellow mosaic virus DNA was significantly increased in ku80 knockout mutants compared with wild-type sibling controls. The possible impact of KU80 on geminivirus multiplication by generating non-productive viral DNAs or its role as a pattern-recognition receptor against DNA virus infection is discussed.
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Authors | Kathrin S Richter, Holger Jeske |
Journal | The Journal of general virology
(J Gen Virol)
Vol. 96
Issue 9
Pg. 2913-2918
(Sep 2015)
ISSN: 1465-2099 [Electronic] England |
PMID | 26297035
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Arabidopsis Proteins
- DNA Helicases
- Ku80 protein, Arabidopsis
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Topics |
- Arabidopsis
(genetics, metabolism, virology)
- Arabidopsis Proteins
(genetics, metabolism)
- Cell Nucleus
(genetics, metabolism, virology)
- DNA End-Joining Repair
- DNA Helicases
(genetics, metabolism)
- Geminiviridae
(genetics, physiology)
- Plant Diseases
(genetics, virology)
- Virus Replication
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