Abstract | BACKGROUND: METHODS: Bone marrow fluids of 88 newly diagnosed AML patients were sampled, and the PCBP1 mRNA expression level was evaluated using quantitative RT-PCR. The association between PCBP1 expression and clinicopathological features or the survival status of the patients was assessed by Chi-square test and Kaplan-Meier method. RESULTS: Comparing newly diagnosed AML patients to normal healthy donors, PCBP1 expression was significantly decreased in AML patients (P < 0.001). Conversely, PCBP1 expression had accordingly recovered back to normal in patients with complete remission (P < 0.001). Clinical feature analyses showed that PCBP1 expression was negatively correlated with white blood cell count (P = 0.024). In addition, patients with low PCBP1 expression had poor disease-free survival (11.8% vs. 45.3%; P = 0.01) and overall survival (18.2% vs. 42.4%; P = 0.032), respectively. CONCLUSIONS: Taken together, our results showed for the first time that expression of PCBP1 was down-regulated in newly diagnosed AML patients and might be an independent prognostic marker in AML and should to be further investigated.
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Authors | Meifeng Zhou, Xiuzhen Tong |
Journal | Diagnostic pathology
(Diagn Pathol)
Vol. 10
Pg. 147
(Aug 21 2015)
ISSN: 1746-1596 [Electronic] England |
PMID | 26293996
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Retracted Publication)
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Chemical References |
- Biomarkers, Tumor
- DNA-Binding Proteins
- Heterogeneous-Nuclear Ribonucleoproteins
- PCBP1 protein, human
- RNA-Binding Proteins
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Topics |
- Adolescent
- Adult
- Aged
- Biomarkers, Tumor
(analysis)
- DNA-Binding Proteins
- Disease-Free Survival
- Down-Regulation
- Female
- Heterogeneous-Nuclear Ribonucleoproteins
(analysis, biosynthesis)
- Humans
- Kaplan-Meier Estimate
- Leukemia, Myeloid, Acute
(metabolism, mortality, pathology)
- Male
- Middle Aged
- Prognosis
- RNA-Binding Proteins
- Reverse Transcriptase Polymerase Chain Reaction
- Young Adult
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