Abstract | INTRODUCTION: METHODS: In this cross-sectional study conducted between October 2012 and April 2013, consecutive adults (>18 years) attending an HIV clinic in Tanzania were enrolled in 3 groups: 153 HIV-negative controls, 151 HIV-infected, ART-naïve, and 150 HIV-infected on ART for ≥ 2 years. The primary outcome was the prevalence of glucose metabolism disorders as determined by oral glucose tolerance testing. We compared glucose metabolism disorder prevalence between each HIV group vs. the control group by Fisher's exact test and used multivariable logistic regression to determine factors associated with glucose metabolism disorders. RESULTS: HIV-infected adults on ART had a higher prevalence of glucose metabolism disorders (49/150 (32.7%) vs.11/153 (7.2%), p<0.001) and frank diabetes mellitus (27/150 (18.0%) vs. 8/153 (5.2%), p = 0.001) than HIV-negative adults, which remained highly significant even after adjusting for age, gender, adiposity and socioeconomic status (OR = 5.72 (2.78-11.77), p<0.001). Glucose metabolism disorders were significantly associated with higher CD4+ T-cell counts. Awareness of diabetes mellitus was <25%. CONCLUSIONS:
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Authors | Emmanuel Maganga, Luke R Smart, Samuel Kalluvya, Johannes B Kataraihya, Ahmed M Saleh, Lama Obeid, Jennifer A Downs, Daniel W Fitzgerald, Robert N Peck |
Journal | PloS one
(PLoS One)
Vol. 10
Issue 8
Pg. e0134410
( 2015)
ISSN: 1932-6203 [Electronic] United States |
PMID | 26287742
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
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Topics |
- Adult
- Anti-HIV Agents
(therapeutic use)
- CD4 Lymphocyte Count
- Cross-Sectional Studies
- Female
- Glucose Metabolism Disorders
(complications, epidemiology, immunology)
- HIV Infections
(complications, drug therapy, epidemiology, immunology)
- Humans
- Hypertension
(complications)
- Male
- Prevalence
- Risk Factors
- Tanzania
(epidemiology)
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