Abstract | BACKGROUND AND PURPOSE: Anti-GQ1b antibodies have been found in patients with Miller Fisher syndrome as well as its related conditions. Our aim was to identify the mechanism by which autoantibodies produce various clinical presentations in 'anti-GQ1b antibody syndrome'. METHODS:
Immunoglobulin G antibodies to ganglioside complex (GSC) of GQ1b or GT1a with GM1, GD1a, GD1b or GT1b were tested in sera from patients with anti-GQ1b (n = 708) or anti-GT1a (n = 696) IgG antibodies. Optical densities of the single anti-GQ1b or anti-GT1a antibodies were used as reference (100%), and those of anti-GSC antibodies were expressed in percentages to reference. The relationships between anti-GSC antibody reactivity and the corresponding clinical features were assessed by multivariate logistic regression analysis. RESULTS: CONCLUSIONS: Differences in fine specificity of anti-GQ1b antibodies are associated with clinical features, possibly due to the different expression of gangliosides in different parts of the nervous system.
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Authors | Y Fukami, A H Y Wong, K Funakoshi, A Y Safri, N Shahrizaila, N Yuki |
Journal | European journal of neurology
(Eur J Neurol)
Vol. 23
Issue 2
Pg. 320-6
(Feb 2016)
ISSN: 1468-1331 [Electronic] England |
PMID | 26176883
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2015 EAN. |
Chemical References |
- Autoantibodies
- Gangliosides
- Immunoglobulin G
- GQ1b ganglioside
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Topics |
- Ataxia
(blood, etiology)
- Autoantibodies
(blood)
- Bulbar Palsy, Progressive
(blood, etiology)
- Disorders of Excessive Somnolence
(blood, etiology)
- Gangliosides
(immunology)
- Guillain-Barre Syndrome
(blood, complications)
- Humans
- Immunoglobulin G
(immunology)
- Miller Fisher Syndrome
(blood, etiology)
- Muscle Weakness
(blood, etiology)
- Ophthalmoplegia
(blood, etiology)
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