Consensus nomenclature for CD8+ T cell phenotypes in cancer.

Abstract

Whereas preclinical investigations and clinical studies have established that CD8+ T cells can profoundly affect cancer progression, the underlying mechanisms are still elusive. Challenging the prevalent view that the beneficial effect of CD8+ T cells in cancer is solely attributable to their cytotoxic activity, several reports have indicated that the ability of CD8+ T cells to promote tumor regression is dependent on their cytokine secretion profile and their ability to self-renew. Evidence has also shown that the tumor microenvironment can disarm CD8+ T cell immunity, leading to the emergence of dysfunctional CD8+ T cells. The existence of different types of CD8+ T cells in cancer calls for a more precise definition of the CD8+ T cell immune phenotypes in cancer and the abandonment of the generic terms "pro-tumor" and "antitumor." Based on recent studies investigating the functions of CD8+ T cells in cancer, we here propose some guidelines to precisely define the functional states of CD8+ T cells in cancer.

• Authors: Lionel Apetoh, Mark J Smyth, Charles G Drake, Jean-Pierre Abastado, Ron N Apte, Maha Ayyoub, Jean-Yves Blay, Marc Bonneville, Lisa H Butterfield, Anne Caignard, Chiara Castelli, Federica Cavallo, Esteban Celis, Lieping Chen, Mario P Colombo, Begoña Comin-Anduix, Georges Coukos, Madhav V Dhodapkar, Glenn Dranoff, Ian H Frazer, Wolf-Hervé Fridman, Dmitry I Gabrilovich, Eli Gilboa, Sacha Gnjatic, Dirk Jäger, Pawel Kalinski, Howard L Kaufman, Rolf Kiessling, John Kirkwood, Alexander Knuth, Roland Liblau, Michael T Lotze, Enrico Lugli, Francesco Marincola, Ignacio Melero, Cornelis J Melief, Thorsten R Mempel, Elizabeth A Mittendorf, Kunle Odun, Willem W Overwijk, Anna Karolina Palucka, Giorgio Parmiani, Antoni Ribas, Pedro Romero, Robert D Schreiber, Gerold Schuler, Pramod K Srivastava, Eric Tartour, Danila Valmori, Sjoerd H van der Burg, Pierre van der Bruggen, Benoît J van den Eynde, Ena Wang, Weiping Zou, Theresa L Whiteside, Daniel E Speiser, Drew M Pardoll, Nicholas P Restifo, Ana C Anderson
• Journal: Oncoimmunology (Oncoimmunology) Vol. 4 Issue 4 Pg. e998538 (Apr 2015) ISSN: 2162-4011 [Print] United States
• PMID: 26137416 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)