Neuromuscular disorders and sleep in critically ill patients.

Abstract

Sleep-disordered breathing (SDB) is a frequent presenting manifestation of neuromuscular disorders and can lead to significant morbidity and mortality. If not recognized and addressed early in the clinical course, SDB can lead to clinical deterioration with respiratory failure. The pathophysiologic basis of SDB in neuromuscular disorders, clinical features encountered in specific neuromuscular diseases, and diagnostic and management strategies for SDB in neuromuscular patients in the critical care setting are reviewed. Noninvasive positive pressure ventilation has been a crucial advance in critical care management, improving sleep quality and often preventing or delaying mechanical ventilation and improving survival in neuromuscular patients.

• Authors: Muna Irfan, Bernardo Selim, Alejandro A Rabinstein, Erik K St Louis
• Journal: Critical care clinics (Crit Care Clin) Vol. 31 Issue 3 Pg. 533-50 (Jul 2015) ISSN: 1557-8232 [Electronic] United States
• PMID: 26118919 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Review)
• Copyright: Copyright © 2015 Elsevier Inc. All rights reserved.

Topics

• Critical Illness
• Humans
• Hypoventilation
• Neuromuscular Diseases (complications, physiopathology)
• Respiration, Artificial
• Sleep (physiology)
• Sleep Apnea Syndromes (etiology, mortality)
• Sleep Wake Disorders (etiology)