Abstract |
Gemcitabine is known to exert a therapeutic effect on brain tumors despite the limited permeability of the blood-brain barrier (BBB). In our experimental research single intraperitoneal (i.p.) injection of gemcitabine 25 mg/kg provided increase in median survival of mice with intracranially transplanted Ehrlich carcinoma by 41-89% (p < 0.001). In this experimental model i.p. administration of gemcitabine (permeability of the BBB of less than 10%), carmustine (good permeability of the BBB), cyclophosphamide (poor permeability of the BBB) and cisplatin (doesn't penetrate through the BBB) increased median survival of mice by 88% (p < 0.001), 59% (p = 0.001), 35% (p = 0.005) and 18% (p = 0.302) respectively. Considering strong correlation between antitumor activity of the drugs ( carmustine, cyclophosphamide and cisplatin) and their permeability of the BBB, efficacy of gemcitabine in intracranial tumors could be due to its wide range of therapeutic doses.
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Authors | A N Stukov, L V Filatova, D Kh Latipova, V G Bespalov, O A Belyaeva, G S Kireeva, I N Vasilieva, V A Alexandrov, M A Maidin, A L Semenov, S F Vershinina, A B Markochev, N Kh Abduloeva, V A Chubenko, T Yu Semiglazova |
Journal | Voprosy onkologii
(Vopr Onkol)
Vol. 61
Issue 2
Pg. 274-9
( 2015)
ISSN: 0507-3758 [Print] Russia (Federation) |
PMID | 26087611
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Antimetabolites, Antineoplastic
- Deoxycytidine
- Cyclophosphamide
- Cisplatin
- Carmustine
- Gemcitabine
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Topics |
- Animals
- Antimetabolites, Antineoplastic
(administration & dosage, pharmacology)
- Antineoplastic Combined Chemotherapy Protocols
(pharmacology)
- Blood-Brain Barrier
(drug effects, metabolism)
- Brain Neoplasms
(drug therapy, etiology)
- Carcinoma, Ehrlich Tumor
(drug therapy)
- Carmustine
(administration & dosage)
- Cisplatin
(administration & dosage)
- Cyclophosphamide
(administration & dosage)
- Deoxycytidine
(administration & dosage, analogs & derivatives, pharmacology)
- Injections, Intraperitoneal
- Male
- Mice
- Neoplasm Transplantation
- Gemcitabine
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