NSAID Use and Incident Cognitive Impairment in a Population-based Cohort.
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| Abstract |
Nonsteroidal anti-inflammatory drugs (NSAIDs) may prevent dementia, but previous studies have yielded conflicting results. This study estimated the association of prior NSAID use with incident cognitive impairment in the population-based Epidemiology of Hearing Loss Study (EHLS, n=2422 without cognitive impairment in 1998-2000). Prospectively collected medication data from 1988-1990, 1993-1995, and 1998-2000 were used to categorize NSAID use history at the cognitive baseline (1998-2000). Aspirin use and nonaspirin NSAID use were separately examined. Cox regression models were used to estimate the associations between NSAID use history at baseline and incident cognitive impairment in 2003-2005 or 2009-2010. Logistic regression analyses were used to estimate associations with a second outcome, mild cognitive impairment/dementia, available in 2009-2010. Participants using aspirin at baseline but not 5 years prior were more likely to develop cognitive impairment (adjusted hazard ratio=1.77; 95% confidence interval=1.11, 2.82; model 2), with nonsignificant associations for longer term use. Nonaspirin NSAID use was not associated with incident cognitive impairment or mild cognitive impairment/dementia odds. These results provided no evidence to support a potential protective effect of NSAIDs against dementia.
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| Authors | Margarete A Wichmann, Karen J Cruickshanks, Cynthia M Carlsson, Rick Chappell, Mary E Fischer, Barbara E K Klein, Ronald Klein, Carla R Schubert |
| Journal | Alzheimer disease and associated disorders (Alzheimer Dis Assoc Disord) 2016 Apr-Jun Vol. 30 Issue 2 Pg. 105-12 ISSN: 1546-4156 [Electronic] United States |
| PMID | 26079710 (Publication Type: Journal Article, Research Support, N.I.H., Extramural) |
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