Outcome is unchanged by adding vincristine upfront to the Malawi 28-day protocol for endemic Burkitt lymphoma.

Abstract

BACKGROUND:

We previously reported a 28-day treatment protocol for children with endemic Burkitt lymphoma (BL) which included four doses of cyclophosphamide (CPM), intrathecal methotrexate and hydrocortisone (IT MTX/HC) at Queen Elizabeth Central Hospital (QECH) in Malawi which resulted in an Event-Free Survival (EFS) of 50% at 1 year.

METHODS:

In an attempt to improve survival whilst maintaining acceptable toxicity, brevity, low-cost and a standard treatment for all patients, four doses of vincristine (VCR) at 1.5 mg/m(2) were added to the backbone of CPM 40 mg/kg on day 1 and 60 mg/kg on days 8,18 and 28 and IT MTX /HC 12.5 mg on days 1,8,18 and 28.

RESULTS:

Seventy cytology confirmed cases of BL, 42 males and 28 females with a median age of 80 years, were treated with this protocol between January 2010 and April 2012. Four percent had St Jude Stage I disease; 29% Stage II; 30% Stage III and 37% Stage IV. Disease site in order of frequency was face (64%); abdomen (47%); CSF (26%) and paraspinal (17%). There were two on-treatment deaths. Sixty-three percent required antibiotics and 19% required blood transfusion. Eighty-one percent of patients achieved complete clinical remission at day 28. Overall predicted EFS at 1 year was 48%; 100% in Stage I, 83% in Stage II, 24% in Stage III and 32% in Stage IV disease. EFS was significantly worse in patients with Stage III/IV disease (P = 0.002) and paraplegia (P = 0.002).

CONCLUSION:

The addition of vincristine to the Malawi 28 day BL treatment protocol did not improve survival.

• Authors: Sarita Depani, Kondwani Banda, Simon Bailey, Trijn Israels, George Chagaluka, Elizabeth Molyneux
• Journal: Pediatric blood & cancer (Pediatr Blood Cancer) Vol. 62 Issue 11 Pg. 1929-34 (Nov 2015) ISSN: 1545-5017 [Electronic] United States
• PMID: 26052841 (Publication Type: Clinical Trial, Journal Article)
• Copyright: © 2015 Wiley Periodicals, Inc.

Chemical References

• Vincristine
• Cyclophosphamide
• Hydrocortisone
• Methotrexate

Topics

• Adolescent
• Antineoplastic Combined Chemotherapy Protocols (administration & dosage)
• Burkitt Lymphoma (drug therapy, epidemiology, mortality)
• Child
• Child, Preschool
• Cyclophosphamide (administration & dosage)
• Disease-Free Survival
• Endemic Diseases
• Female
• Humans
• Hydrocortisone (administration & dosage)
• Malawi (epidemiology)
• Male
• Methotrexate (administration & dosage)
• Neoplasm Staging
• Survival Rate
• Vincristine (administration & dosage)