A case of relapsing spinal atypical teratoid/rhabdoid tumor (AT/RT) responding to vinorelbine, cyclophosphamide, and celecoxib.

Abstract

INTRODUCTION:

Atypical teratoid/rhabdoid tumor (AT/RT) of the central nervous system is a highly aggressive neoplasm which prevalently affects children and is characterized by a severe prognosis.

CASE PRESENTATION:

The authors describe an extremely rare case of a primary spinal AT/RT that occurred in a young girl. The patient underwent a wide surgical resection of a lumbar mass, followed by aggressive chemotherapy, myeloablative treatment, and local radiotherapy. After 7 months from the end of the treatment, the patient experienced local recurrence and was treated with surgery and second-line chemotherapy with antiangiogenic purposes, consisting of oral vinorelbine, cyclophosphamide, and celecoxib. Treatment was well tolerated, and patient was still alive 36 months after diagnosis.

CONCLUSION:

The peculiarity of this case report is the clinical-radiological response to a metronomic therapy in a case of early-relapsing spinal AT/RT despite previous maximal surgery, chemotherapy, and radiotherapy.

• Authors: Giacomo Gotti, Veronica Biassoni, Elisabetta Schiavello, Filippo Spreafico, Manila Antonelli, Giuseppina Calareso, Emilia Pecori, Lorenza Gandola, Maura Massimino
• Journal: Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery (Childs Nerv Syst) Vol. 31 Issue 9 Pg. 1621-3 (Sep 2015) ISSN: 1433-0350 [Electronic] Germany
• PMID: 26008576 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antineoplastic Agents
• Vinblastine
• Cyclophosphamide
• Celecoxib
• Vinorelbine

Topics

• Antineoplastic Agents (therapeutic use)
• Celecoxib (therapeutic use)
• Cyclophosphamide (therapeutic use)
• Female
• Humans
• Magnetic Resonance Imaging
• Rhabdoid Tumor (drug therapy)
• Spinal Cord Neoplasms (drug therapy)
• Vinblastine (analogs & derivatives, therapeutic use)
• Vinorelbine
• Young Adult