Abstract | CONTEXT: OBJECTIVE: DESIGN, SETTING, AND PARTICIPANTS: This was a cross-sectional analysis of 2009-2012 National Health and Nutrition Examination Surveys (NHANES) composed of 356 fasting 12-19-year-olds. MAIN OUTCOME MEASURES: RESULTS: Controlling for demographic and behavioral factors, diet, age, body mass index, and urinary creatinine, for each log increase in DINP metabolite, a 0.08 (P = .001) increase in HOMA-IR was identified. Compared with the first tertile of DINP (23.4% adjusted prevalence), the third tertile was associated with a 34.4% prevalence (95% confidence interval [CI], 27.3-41.6%; P = .033) of insulin resistance. Similarly, compared with the first tertile of DEHP (20.5% adjusted prevalence), the third tertile had 37.7% prevalence (95% CI 29.8-45.6%; P = .003). CONCLUSIONS: Urinary DINP concentrations were associated with increased insulin resistance in this cross-sectional study of adolescents. The previously identified association of DEHP with insulin resistance was also confirmed. Further, longitudinal studies are needed to confirm these associations, with the possibility to assess opportunities for intervention.
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Authors | Teresa M Attina, Leonardo Trasande |
Journal | The Journal of clinical endocrinology and metabolism
(J Clin Endocrinol Metab)
Vol. 100
Issue 7
Pg. 2640-50
(Jul 2015)
ISSN: 1945-7197 [Electronic] United States |
PMID | 25993640
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- Phthalic Acids
- diisononyl phthalate
- Diethylhexyl Phthalate
- diisodecyl phthalate
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Topics |
- Adolescent
- Adult
- Child
- Cross-Sectional Studies
- Diethylhexyl Phthalate
(metabolism, toxicity, urine)
- Environmental Exposure
(analysis, statistics & numerical data)
- Female
- Food Industry
(methods)
- Humans
- Insulin Resistance
- Male
- Nutrition Surveys
- Phthalic Acids
(metabolism, toxicity, urine)
- Young Adult
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