Abstract | BACKGROUND: High ventricular premature depolarization (VPD) burden is associated with left ventricular ( LV) dysfunction that typically resolves after successful ablation. Some patients, however, have persistent LV dysfunction, even after successful radiofrequency (RF) ablation. Identifying factors associated with irreversibility of LV cardiomyopathy ( CMP) may help predict clinical outcome. METHODS AND RESULTS: Patients with frequent VPD (>10%/day) who underwent successful VPD suppression were divided into 2 groups according to transthoracic echocardiography (TTE) before and after suppression: group A (n=38) had depressed LV function that normalized after VPD suppression; group B (n=19) had depressed LV function before and after suppression. Of 57 patients (43 men; mean age, 54±15 years), RF ablation was performed in 39. Clinical, electrocardiographic, and TTE parameters were compared between groups. LV end-diastolic dimension (LVEDD; group A vs. B: 54±5 mm vs. 60±10 mm, P=0.01), end-systolic dimension (group A vs. B: 42±6 mm vs. 48±11 mm, P=0.01) before VPD suppression differed significantly between groups. Pre-suppression LVEDD was ≤66 mm in all reversible- CMP patients. LVEDD >66 mm predicted irreversible CMP with 50% sensitivity, 100% specificity, 100% positive predictive value, and 81% negative predictive value. CONCLUSIONS: LVEDD was a good predictor of irreversible LV CMP with frequent VPD, with 50% sensitivity and 100% specificity.
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Authors | Kyoung-Min Park, Jihye Kim, Hayoung Na, Kwang Jin Chun, Sung Il Im, Seung-Jung Park, June Soo Kim, Young Keun On |
Journal | Circulation journal : official journal of the Japanese Circulation Society
(Circ J)
Vol. 79
Issue 8
Pg. 1816-22
( 2015)
ISSN: 1347-4820 [Electronic] Japan |
PMID | 25959434
(Publication Type: Clinical Trial, Comparative Study, Journal Article)
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Topics |
- Adult
- Aged
- Cardiomyopathies
(diagnostic imaging, physiopathology, surgery)
- Catheter Ablation
- Female
- Humans
- Male
- Middle Aged
- Ultrasonography
- Ventricular Dysfunction, Left
(diagnostic imaging, physiopathology, surgery)
- Ventricular Premature Complexes
(diagnostic imaging, physiopathology, surgery)
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