Abstract | PURPOSE: To validate the use of bone scintigraphy (BS) versus computed tomography (CT) for therapeutic monitoring in patients during treatment with zoledronic acid. MATERIALS AND METHODS: Eleven patients with bone-only metastatic disease and being treated with zoledronic acid were included. The effects of therapies including chemotherapy and hormone therapy were evaluated in 25 separate examinations in total as follows: complete response (CR), when no bone metastasis was visible; partial response (PR), when a decrease in the lesion area was detected; stable disease (SD), when no or slight change was observed; and progressive disease (PD), when new or enlarged lesion areas were observed. RESULTS: The accuracies of examination by Readers 1, 2, and 3 respectively were 76%, 80% and 76% for BS, 52%, 48%, and 40% for CT, and 64%, 52% and 60% for BS and CT combined with Readers 2 and 3 observing significant differences between CT and BS results. The rates of interobserver agreement between Readers 1 and 2, between Readers 1 and 3, and between Reader 2 and 3 respectively, were 84%, 80% and 88% (κ = 0.648, 0.561 and 0.766) for BS, 52%, 56%, and 60% (κ = 0.180, 0.278 and 0.282) for CT, and 52%, 60%, and 56% (κ = 0.215, 0.282 and 0.232) for CT and BS combined. CONCLUSION:
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Authors | Shirou Ishii, Ken Kikuchi, Masayuki Miyajima, Kotaro Sakuma, Fumio Shishido |
Journal | Fukushima journal of medical science
(Fukushima J Med Sci)
Vol. 61
Issue 1
Pg. 23-31
( 2015)
ISSN: 2185-4610 [Electronic] Japan |
PMID | 25946906
(Publication Type: Comparative Study, Journal Article, Validation Study)
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Chemical References |
- Bone Density Conservation Agents
- Diphosphonates
- Imidazoles
- Fluorodeoxyglucose F18
- Zoledronic Acid
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Topics |
- Adult
- Aged
- Bone Density Conservation Agents
(therapeutic use)
- Bone Neoplasms
(diagnostic imaging, drug therapy, secondary)
- Bone and Bones
(diagnostic imaging)
- Breast Neoplasms
(pathology)
- Diphosphonates
(therapeutic use)
- Female
- Fluorodeoxyglucose F18
- Humans
- Imidazoles
(therapeutic use)
- Middle Aged
- Positron-Emission Tomography
- Tomography, X-Ray Computed
- Zoledronic Acid
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