The objective of the present study was to estimate the clinical effectiveness of
fenspiride used to correct the obstruction of the Eustachian tube in 80 patients presenting with acute tubootitis and exudative
otitis media. The algorithm of the examination included the evaluation of the severity of subjective clinical symptoms based on the relevant analog-visual scale, results of tonal audiometry, and tympanometry. The control group was comprised of 34 patients treated with antibacterial preparations, topical
decongestants, and transtubal administration of
glucocorticoids. The study group included 46 patients who received
fenspiride at a dose of 80 mg thrice daily in addition to the above
pharmacotherapy. The severity of clinical symptoms in the patients treated with
fenspiride decreased faster than in the control subjects. The frequency analysis of dynamics of the air-bone gaps on the audiometric curves revealed the significantly more intensive recovery of the hearing function in the patients treated by basal
pharmacotherapy in the combination with
fenspiride. Type A tympanograms predominated on day 7 after the onset of the
conservative treatment with the use of
fenspiride whereas type C tympanograms continued to predominate in the patients of the control group. It is concluded that the introduction of
fenspiride into combined
therapy of acute tubootitis and exudative
otitis media promotes the normalization of the ventilation and drainage functions and relieves the severity of subjective clinical symptoms.