Abstract | BACKGROUND: METHODS AND FINDINGS: RESULTS: Forty-eight of 66 patients developed AKI (AKIN criteria), with 37 (56%) developing moderate to severe AKI (AKIN stage 2 or 3). The 37 patients showed rapid increases in creatinine of >100% within 24 hours, >200% within 48 hours and >300% by 72 hours and 17 of the 37 died. CysC concentration increased by 50% at 24 hours in the same 37 patients and then remained constant. The creatinine/CysC ratio increased 8 fold over 72 hours. There was a modest fall in urinary creatinine and serum/urine creatinine ratios and a moderate increase in urinary paraquat during first three days. CONCLUSION:
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Authors | Fahim Mohamed, Zoltan Endre, Shaluka Jayamanne, Timothy Pianta, Philip Peake, Chathura Palangasinghe, Umesh Chathuranga, Kithsiri Jayasekera, Klintean Wunnapuk, Fathima Shihana, Seyed Shahmy, Nicholas Buckley |
Journal | PloS one
(PLoS One)
Vol. 10
Issue 3
Pg. e0122357
( 2015)
ISSN: 1932-6203 [Electronic] United States |
PMID | 25815837
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- Cystatin C
- Creatinine
- Paraquat
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Topics |
- Acute Kidney Injury
(blood, chemically induced, urine)
- Adult
- Biomarkers
(blood, urine)
- Creatinine
(blood, urine)
- Cystatin C
(blood, urine)
- Female
- Glomerular Filtration Rate
(drug effects)
- Humans
- Kidney
(drug effects, pathology)
- Male
- Middle Aged
- Paraquat
(toxicity)
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