Abstract |
The aim of this study was to demonstrate the clinicopathological features, prognostic outcomes and fibroblast growth factor receptor 3 ( FGFR3) protein expression status of a large series (n = 45) of urothelial carcinoma of bladder patients aged 30 or younger, retrospectively. We identified an age gradient (an age of 25, 26 and 27 years), classified patients as ≤ 25 or >25, ≤ 26 or >26, ≤ 27 or >27 years, respectively, and compared variables including recurrence events and FGFR3 expression patterns between different groups. Patients aged 25 years or younger were less likely to experience tumor recurrence (p = 0.046), were more likely to develop smaller size tumors (p = 0.040) and expressed more proportion of negative pattern of FGFR3 protein (p = 0.036). Patients aged 25 years or younger were less likely to develop tumor recurrence and revealed more proportion of negative pattern of FGFR3 expression than those aged 26-30 years did. We identified patients aged 25 years or younger as the true "young" urothelial carcinoma patients, carrying distinct clinical outcomes and molecular tumorigenesis.
|
Authors | Haichao Huang, Mengkui Sun, Xin Li, Jie Jin |
Journal | Medical oncology (Northwood, London, England)
(Med Oncol)
Vol. 32
Issue 5
Pg. 137
(May 2015)
ISSN: 1559-131X [Electronic] United States |
PMID | 25801230
(Publication Type: Journal Article)
|
Chemical References |
- FGFR3 protein, human
- Receptor, Fibroblast Growth Factor, Type 3
|
Topics |
- Adult
- Carcinoma
(metabolism, pathology)
- Female
- Humans
- Male
- Neoplasm Recurrence, Local
(metabolism, pathology)
- Prognosis
- Receptor, Fibroblast Growth Factor, Type 3
(metabolism)
- Retrospective Studies
- Urinary Bladder
(metabolism, pathology)
- Urinary Bladder Neoplasms
(metabolism, pathology)
- Urothelium
(metabolism, pathology)
|