Effect of intravariceal sclerotherapy combined with esophageal mucosal sclerotherapy using small-volume sclerosant for cirrhotic patients with high variceal pressure.

Abstract

AIM:

To explore the effect of intravariceal-mucosal sclerotherapy using small dose of sclerosant on the recurrence of esophageal varices.

METHODS:

We randomly assigned 38 cirrhotic patients with previous variceal bleeding and high variceal pressure (> 15.2 mmHg) to receive endoscopic variceal ligation (EVL) and combined intravariceal and esophageal mucosal sclerotherapy (combined group) using small-volume sclerosant. The end-points of the study were rebleeding and recurrence of esophageal varices.

RESULTS:

During a median follow-up period of 16 mo, varices recurred in 1 patient in the combined group as compared with 7 patients in the EVL group (P = 0.045). Rebleeding occurred in 3 patients in the EVL group as compared with 1 patient in the combined group (P = 0.687). No patient died in the two groups. No significant differences were observed between the two groups with respect to serious adverse events.

CONCLUSION:

Intravariceal-mucosal sclerotherapy using small dose of sclerosant is more effective than EVL in decreasing the incidence of variceal recurrence for cirrhotic patients.

• Authors: De-Run Kong, Jin-Guang Wang, Chen Chen, Fang-Fang Yu, Qiong Wu, Jian-Ming Xu
• Journal: World journal of gastroenterology (World J Gastroenterol) Vol. 21 Issue 9 Pg. 2800-6 (Mar 07 2015) ISSN: 2219-2840 [Electronic] United States
• PMID: 25759552 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Sclerosing Solutions
• Polyethylene Glycols

Topics

• Adult
• Aged
• China
• Esophageal and Gastric Varices (diagnosis, etiology, therapy)
• Esophagoscopy (adverse effects)
• Female
• Gastrointestinal Hemorrhage (diagnosis, etiology, therapy)
• Humans
• Injections, Intralesional
• Liver Cirrhosis (complications, diagnosis)
• Male
• Middle Aged
• Polyethylene Glycols (administration & dosage, adverse effects)
• Pressure
• Prospective Studies
• Recurrence
• Risk Factors
• Sclerosing Solutions (administration & dosage, adverse effects)
• Sclerotherapy (adverse effects, methods)
• Time Factors
• Treatment Outcome