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Aberrant cytokine production by nonmalignant cells in the pathogenesis of myeloproliferative tumors and response to JAK inhibitor therapies.

Abstract
Kleppe and colleagues use detailed cytokine profiling analyses to investigate the role of aberrant proinflammatory cytokine secretion in the pathogenesis of myeloproliferative neoplasms. Their analyses implicate constitutive activation of STAT3 in both malignant and nonmalignant bone marrow cell populations as a driver of aberrant cytokine secretion and as a cellular target mediating the therapeutic activity of ruxolitinib.
AuthorsLaura Belver, Adolfo A Ferrando
JournalCancer discovery (Cancer Discov) Vol. 5 Issue 3 Pg. 234-6 (Mar 2015) ISSN: 2159-8290 [Electronic] United States
PMID25749974 (Publication Type: Journal Article, Comment)
Copyright©2015 American Association for Cancer Research.
Chemical References
  • STAT Transcription Factors
  • Janus Kinases
Topics
  • Animals
  • Cell Transformation, Neoplastic (metabolism)
  • Humans
  • Janus Kinases (metabolism)
  • Myeloproliferative Disorders (metabolism)
  • STAT Transcription Factors (metabolism)
  • Signal Transduction

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