Abstract | BACKGROUND: OBJECTIVES: We conducted a nested case-control study, using prospectively collected serum, to estimate associations between OC exposures and metastatic prostate cancer in a population-based cohort from Norway. METHODS: Sera from 150 cases and 314 controls matched on date of blood draw, age at blood draw, and region was used to determine concentrations of 11 OC pesticide metabolites and 34 PCB congeners. Odds ratios ( ORs) and 95% confidence intervals (95% CIs) for quartiles of lipid-corrected metabolite levels were calculated using conditional logistic regression. RESULTS: Metastatic prostate cancer was two times as likely among men with serum concentrations of oxychlordane in the highest quartile compared with those in the lowest quartile (OR = 2.03; 95% CI: 1.03, 4.03; p-trend 0.05). Elevated but nonsignificant ORs were estimated for the highest versus lowest quartile of heptachlor epoxide, HCB, and mirex, although these exposures were correlated with oxychlordane. Findings for specific PCB congeners showed a significant inverse association between natural log-transformed lipid-adjusted PCB 44 and metastatic prostate cancer (OR = 0.74; 95% CI: 0.56, 0.97; p-trend = 0.02). CONCLUSIONS: Our study highlights the importance of estimating associations with specific OC chemicals and suggests a possible role of OC insecticides and PCBs in the etiology of metastatic prostate cancer. CITATION: Koutros S, Langseth H, Grimsrud TK, Barr DB, Vermeulen R, Portengen L, Wacholder S, Beane Freeman LE, Blair A, Hayes RB, Rothman N, Engel LS. 2015. Prediagnostic serum organochlorine concentrations and metastatic prostate cancer: a nested case-control study in the Norwegian Janus Serum Bank cohort. Environ Health Perspect 123:867-872; http://dx.doi.org/10.1289/ehp.1408245.
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Authors | Stella Koutros, Hilde Langseth, Tom K Grimsrud, Dana Boyd Barr, Roel Vermeulen, Lützen Portengen, Sholom Wacholder, Laura E Beane Freeman, Aaron Blair, Richard B Hayes, Nathaniel Rothman, Lawrence S Engel |
Journal | Environmental health perspectives
(Environ Health Perspect)
Vol. 123
Issue 9
Pg. 867-72
(Sep 2015)
ISSN: 1552-9924 [Electronic] United States |
PMID | 25734605
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Hydrocarbons, Chlorinated
- Insecticides
- Polychlorinated Biphenyls
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Topics |
- Adult
- Aged
- Case-Control Studies
- Humans
- Hydrocarbons, Chlorinated
(blood)
- Insecticides
(blood)
- Logistic Models
- Male
- Middle Aged
- Neoplasm Metastasis
- Norway
- Polychlorinated Biphenyls
(blood)
- Prospective Studies
- Prostatic Neoplasms
(blood, chemically induced, pathology)
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