[Effectiveness of chemoradiotherapy for a patient with local recurrence of advanced gastric cancer followed by curable gastrectomy].

Abstract

We report here the effectiveness of chemoradiotherapy for a patient with local recurrence followed by curable gastrectomy. A 57-year-old man presented with a history of total gastrectomy with distal pancreatectomy and splenectomy, D2 lymphadenectomy, and Roux-en-Y reconstruction for advanced gastric cancer arising from the cardia. Esophageal intramural metastasis and lymph node metastasis around the right recurrent nerve were detected by chest-abdominal computed tomography and gastrointestinal endoscopy 27 months after the initial gastrectomy. Stable disease was achieved following 7 courses of chemotherapy using S-1 plus CDDP. Concurrent chemoradiotherapy including administration of S-1 and radiation of total 50 Gy (2 Gy/25 Fr) was selected for local tumor control. The patient was not able to eat solid food because of esophageal stenosis from regrowth of intramural metastasis of the esophagus 60 months after the chemotherapy. A WallFlex™ Duodenal Stent was placed to improve the dysphagia 67 months after chemotherapy. The patient died from recurrence of gastric cancer 69 months after completion of the initial chemotherapy and 2 months after the stent insertion.

• Authors: Soichiro Natsume, Yoshiaki Iwasaki, Kazuhito Yajima, Ken Yuu, Ryouki Oohinata, Satoshi Ishiyama, Keiichi Takahashi, Yoshiharu Maeda
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 41 Issue 12 Pg. 2326-8 (Nov 2014) ISSN: 0385-0684 [Print] Japan
• PMID: 25731511 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Drug Combinations
• S 1 (combination)
• Tegafur
• Oxonic Acid
• Cisplatin

Topics

• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Chemoradiotherapy
• Cisplatin (administration & dosage)
• Drug Combinations
• Esophageal Neoplasms (secondary, therapy)
• Gastrectomy
• Humans
• Male
• Middle Aged
• Oxonic Acid (administration & dosage)
• Recurrence
• Stomach Neoplasms (pathology, therapy)
• Tegafur (administration & dosage)