Arginine promotes fluoride uptake into artificial carious lesions in vitro.

Abstract

BACKGROUND:

This study focused on the interaction of arginine and fluoride on the remineralization of artificial enamel carious lesions in vitro.

METHODS:

Human enamel blocks with artificial carious lesions were prepared and randomly divided into six treatment groups (n=30 for each group): deionized water, arginine solution, NaF solution, arginine/NaF solution, arginine-free fluoride toothpaste slurry and arginine-containing fluoride toothpaste slurry. After a pH-cycling regimen for 10 days, subsets of specimens from each group were subjected to independent analysis, including surface microhardness (n=8/30), cross-sectional microhardness (n=8/30), enamel fluoride uptake (n=8/30) and polarized light microscopy (n=6/30). The samples tested for surface microhardness were further subjected to simulated plaque acid challenge before surface microhardness was remeasured.

RESULTS:

Arginine solution promoted remineralization compared with deionized water control (p<0.05). When used in combination with fluoride, arginine significantly increased fluoride uptake compared with fluoride alone (p<0.05). In addition, lesions treated with arginine-containing toothpaste also showed superior fluoride uptake compared with those treated with conventional fluoride toothpaste (p<0.05).

CONCLUSIONS:

Arginine promoted enamel fluoride uptake when used in combination with fluoride, thereby contributing to resistance of enamel to carious demineralization.

• Authors: X Cheng, P Xu, X Zhou, M Deng, L Cheng, M Li, Y Li, X Xu
• Journal: Australian dental journal (Aust Dent J) Vol. 60 Issue 1 Pg. 104-11 (Mar 2015) ISSN: 1834-7819 [Electronic] Australia
• PMID: 25721284 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2015 Australian Dental Association.

Chemical References

• Cariostatic Agents
• Phosphates
• pro-argin
• Sodium Fluoride
• Arginine
• Calcium Carbonate
• Fluorides

Topics

• Anatomy, Cross-Sectional
• Arginine (pharmacokinetics, pharmacology)
• Calcium Carbonate (pharmacokinetics, pharmacology)
• Cariostatic Agents (pharmacokinetics, pharmacology)
• Dental Caries (metabolism)
• Dental Enamel (drug effects, metabolism)
• Dental Plaque (metabolism)
• Fluorides (pharmacokinetics, pharmacology)
• Hardness
• Humans
• Hydrogen-Ion Concentration
• Materials Testing
• Microscopy, Polarization
• Phosphates (pharmacokinetics, pharmacology)
• Sodium Fluoride (pharmacokinetics, pharmacology)
• Tooth Demineralization (metabolism)
• Tooth Remineralization (methods)