Abstract | BACKGROUND: METHODS AND RESULTS: We compared sex-specific death risk in 75 079 patients with New York Heart Association class III or IV heart failure, reduced left ventricular ejection fraction, and prolonged QRS duration (≥120 ms) receiving either CRT-D or implantable cardioverter defibrillator in subgroups according to QRS morphology and 10-ms increments in QRS duration. We applied propensity score weighting to control for differences between treatments. Among patients with LBBB, women receiving CRT-D had a lower relative death risk than those receiving an implantable cardioverter-defibrillator (absolute difference, 11%; hazard ratio=0.74 [95% confidence interval, 0.68-0.81]). In men, the lower mortality with CRT-D versus implantable cardioverter defibrillator was less pronounced (absolute difference, 9%; hazard ratio=0.84 [0.79-0.89]; sex×device interaction P=0.025). In those without LBBB, the mortality difference was modest and did not differ between women and men (absolute difference, 3%; hazard ratio=0.88 [0.79-0.97] in women and absolute difference, 2%; hazard ratio=0.95 [0.91-0.998] in men; interaction P=0.17). In subgroups according to QRS duration, CRT-D was associated with better survival in both sexes with LBBB and QRS ≥130 ms, whereas there was no clear relation between QRS duration and survival in patients without LBBB regardless of patient sex. CONCLUSIONS: In a large real-world population CRT-D was associated with a lower mortality risk in both sexes with LBBB, although more pronounced among women. Only among those with LBBB, both sexes had better survival with longer QRS duration. The mortality differences in patients without LBBB were attenuated in both sexes.
|
Authors | Robbert Zusterzeel, Erica S Spatz, Jeptha P Curtis, William E Sanders, Kimberly A Selzman, Ileana L Piña, Haikun Bao, Angelo Ponirakis, Paul D Varosy, Frederick A Masoudi, Daniel A Caños, David G Strauss |
Journal | Circulation. Cardiovascular quality and outcomes
(Circ Cardiovasc Qual Outcomes)
Vol. 8
Issue 2 Suppl 1
Pg. S4-11
(Mar 2015)
ISSN: 1941-7705 [Electronic] United States |
PMID | 25714821
(Publication Type: Comparative Study, Journal Article, Observational Study, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)
|
Copyright | © 2015 American Heart Association, Inc. |
Topics |
- Aged
- Aged, 80 and over
- Bundle-Branch Block
(diagnosis, mortality, physiopathology, therapy)
- Cardiac Resynchronization Therapy
(adverse effects, mortality)
- Cardiac Resynchronization Therapy Devices
- Defibrillators, Implantable
- Electric Countershock
(adverse effects, instrumentation, mortality)
- Female
- Health Status Disparities
- Heart Conduction System
(physiopathology)
- Heart Failure
(diagnosis, mortality, physiopathology, therapy)
- Humans
- Kaplan-Meier Estimate
- Male
- Propensity Score
- Proportional Hazards Models
- Registries
- Risk Factors
- Sex Factors
- Stroke Volume
- Treatment Outcome
- United States
- Ventricular Function, Left
|