Serum vaspin levels: A possible correlation with digital ulcers in patients with systemic sclerosis.

Abstract

Vaspin is an adipokine implicated in vascular inflammation and remodeling. We herein evaluated the clinical correlation of serum vaspin levels in systemic sclerosis (SSc). Consistent with previous reports, 12% of subjects exhibited serum vaspin levels over 10 ng/mL, likely due to genetic effects. Excluding these subjects, despite no difference between SSc and control subjects, serum vaspin levels were significantly decreased in SSc patients with digital ulcers compared with those without, suggesting the potential contribution of vaspin to digital ulcers of this disease.

• Authors: Shunsuke Miura, Yoshihide Asano, Ryosuke Saigusa, Takashi Yamashita, Takashi Taniguchi, Takehiro Takahashi, Yohei Ichimura, Tetsuo Toyama, Zenshiro Tamaki, Yayoi Tada, Makoto Sugaya, Shinichi Sato, Takafumi Kadono
• Journal: The Journal of dermatology (J Dermatol) Vol. 42 Issue 5 Pg. 528-31 (May 2015) ISSN: 1346-8138 [Electronic] England
• PMID: 25708680 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2015 Japanese Dermatological Association.

Chemical References

• SERPINA12 protein, human
• Serpins

Topics

• Aged
• Female
• Fingers
• Humans
• Male
• Middle Aged
• Scleroderma, Systemic (blood, complications)
• Serpins (blood)
• Skin Ulcer (blood, complications)
• Toes