Abstract | INTRODUCTION: PATIENTS AND METHODS: A total of 117 patients with IBTR without distant metastases were enrolled in this study. All patients were examined for estrogen receptor (ER), HER2, and Ki-67 in both the primary tumors and paired IBTR. We evaluated the impact of changes in these biomarkers between primary tumors and IBTR on the prognosis after IBTR. RESULTS: There were no associations of changes in the ER, HER2 status with distant disease-free survival (DDFS) after surgical resection of IBTR, whereas the change in the Ki-67 status between the primary tumors and IBTR was significantly correlated with DDFS (unadjusted: p = 0.0094; adjusted: p = 0.013). Patients in the "increased or remained high" Ki-67 group had a significantly shorter DDFS than those in the "decreased or remained low" Ki-67 group (5-year DDFS: 55.5 vs. 79.3%, respectively, p = 0.0084 by log-rank test). CONCLUSION: An increased or persistently high Ki-67 status in the IBTR was significantly correlated with a poorer prognosis after IBTR.
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Authors | Y Okumura, R Nishimura, K Nakatsukasa, A Yoshida, N Masuda, M Tanabe, T Shien, S Tanaka, N Arima, Y Komoike, T Taguchi, T Iwase, H Inaji, M Ishitobi, Collaborative Study Group of Scientific Research of the Japanese Breast Cancer Society |
Journal | European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
(Eur J Surg Oncol)
Vol. 41
Issue 4
Pg. 548-52
(Apr 2015)
ISSN: 1532-2157 [Electronic] England |
PMID | 25682910
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2015 Elsevier Ltd. All rights reserved. |
Chemical References |
- Biomarkers, Tumor
- Ki-67 Antigen
- Receptors, Estrogen
- ERBB2 protein, human
- Receptor, ErbB-2
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Topics |
- Adult
- Aged
- Biomarkers, Tumor
(analysis)
- Breast Neoplasms
(chemistry, pathology, surgery)
- Disease-Free Survival
- Female
- Humans
- Immunohistochemistry
- Ki-67 Antigen
(analysis)
- Mastectomy, Segmental
- Middle Aged
- Neoplasm Grading
- Neoplasm Recurrence, Local
(chemistry, pathology, surgery)
- Receptor, ErbB-2
(analysis)
- Receptors, Estrogen
(analysis)
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