Abstract | OBJECTIVE: MATERIALS AND METHODS: This study investigated the effects of LAC, RAM and VAL on serum BNP levels in acute and chronic periods after ISO-induced MI in rats. RESULTS: Serum BNP was found to be significantly increased in the acute MI model, but not in the chronic MI model. RAM and VAL application decreased BNP levels that had been increased after acute MI induction. Additionally, no significant differences were seen in chronic MI+drug groups compared with both intact and chronically infarcted control groups. CONCLUSION: The acute MI model, but not the chronic MI model, was associated with increased serum BNP levels. Pre-treatment with RAM and VAL, but not LAC, prevented the acute MI-induced increase in serum BNP levels, suggesting that inhibition of the renin-angiotensin system has prophylactic effects in the acute MI model. Therefore, both RAM and VAL may become first-line drugs for the treatment of hyper-tensive patients who are at high risk for cardiovascular failure.
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Authors | Yasin Bayir, Elif Cadirci, Halis Suleyman, Zekai Halici, Mevlut Sait Keles |
Journal | The Eurasian journal of medicine
(Eurasian J Med)
Vol. 41
Issue 1
Pg. 44-8
(Apr 2009)
ISSN: 1308-8734 [Print] Turkey |
PMID | 25610063
(Publication Type: Journal Article)
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