Abstract | BACKGROUND: PURPOSE: Here, we performed a cross-sectional study to evaluate the association between the Arg/ADMA ratio and the maximal intima-media thickness (IMT) in the carotid artery. SUBJECTS AND METHODS: Participants were 785 community-dwelling Japanese people without any severe disorders. Plasma concentration of Arg and ADMA in fasting blood sample was determined using HPLC. IMT was measured in the bilateral carotid artery by ultrasonography. RESULTS: Among quartiles stratified by the Arg/ADMA ratio, ANOVA showed a significant difference in IMT and the IMT in Q1 (the lowest quartile) was significantly higher than that in Q4 (the highest quartile). In multiple linear regression analysis, age, the male gender, lower BMI, the presence of hypertension and lower Arg/ADMA ratio were independently correlated with IMT, while IMT was not correlated with Arg or ADMA alone. In addition, the Arg/ADMA ratio was associated with IMT independent of age, sex, BMI and the presence of hypertension with odds ratio 0.21 (95%CI: 0.05-0.88) in multiple logistic regression analysis for IMT 1.5 mm or more. CONCLUSION: Imbalance of Arg and ADMA is independently involved in the progression of atherosclerosis, and the Arg/ADMA ratio may be a sensitive marker for atherosclerosis.
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Authors | Yoshitomo Notsu, Shozo Yano, Hiroshi Shibata, Atsushi Nagai, Toru Nabika |
Journal | Atherosclerosis
(Atherosclerosis)
Vol. 239
Issue 1
Pg. 61-6
(Mar 2015)
ISSN: 1879-1484 [Electronic] Ireland |
PMID | 25576847
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2014 Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
- Biomarkers
- N,N-dimethylarginine
- Arginine
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Topics |
- Aged
- Arginine
(analogs & derivatives, blood)
- Atherosclerosis
(blood, physiopathology)
- Biomarkers
(blood)
- Blood Pressure
- Body Mass Index
- Carotid Arteries
(diagnostic imaging)
- Carotid Artery, Common
(diagnostic imaging)
- Carotid Intima-Media Thickness
- Cohort Studies
- Cross-Sectional Studies
- Female
- Humans
- Hypertension
(blood, physiopathology)
- Japan
- Male
- Middle Aged
- Risk Factors
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