The complex association of metabolic syndrome and its components with computed tomography-determined emphysema index.

Abstract

BACKGROUND:

Recent reports have suggested the association between emphysema and cardiovascular disease (CVD); however, there are few reports regarding association of emphysema severity with metabolic syndrome and its components representing CVD risk factors.

METHODS:

A retrospective cross-sectional study was performed in 2814 adult male subjects over age 40 who visited the Health Promotion Center in Samsung Medical Center for a health checkup program.

RESULTS:

We classified patients according to the quintiles of forced expiratory volume in 1 sec (FEV1) and emphysema index (EI). FEV1 percentage predicted values (% pred) was inversely associated with prevalence of metabolic syndrome and most of its components, such as abdominal obesity, hypertension, fasting hyperglycemia, and low high-density lipoprotein cholesterol. Although there was no association between prevalence of metabolic syndrome and EI, hypertension was positively associated with EI (P<0.001) and high triglycerides (TGs) were inversely associated with EI (P=0.021). These associations persisted after adjustment of other variables (P<0.001 in hypertension and P=0.039 in high TGs).

CONCLUSION:

The computed tomography-determined EI has a complex association with components of metabolic syndrome that is associated with increased prevalence of hypertension but decreased prevalence of high TGs, whereas FEV1 (% pred) has an inverse association with metabolic syndrome and most of its components with consistent direction.

• Authors: Hye Yun Park, Byung Woo Jhun, Ho Jung Jeong, Hae Ri Chon, Won-Jung Koh, Gee Young Suh, Hojoong Kim, Myung Jin Chung, Hee Jung Jun, Yoon-Ho Choi, Seong Yong Lim
• Journal: Metabolic syndrome and related disorders (Metab Syndr Relat Disord) Vol. 13 Issue 3 Pg. 132-9 (Apr 2015) ISSN: 1557-8518 [Electronic] United States
• PMID: 25569241 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Cholesterol, HDL

Topics

• Adult
• Aged
• Anthropometry
• Cardiovascular Diseases (complications, diagnostic imaging)
• Cholesterol, HDL (blood)
• Cross-Sectional Studies
• Emphysema (complications, radiotherapy)
• Forced Expiratory Volume
• Humans
• Male
• Metabolic Syndrome (complications, diagnostic imaging)
• Middle Aged
• Predictive Value of Tests
• Prevalence
• Retrospective Studies
• Risk Factors
• Tomography, X-Ray Computed