[Advance in studies on antitumor and immunomodulatory effects of wogonin].

Abstract

Wogonin is a kind of natural flavonoid compound. According to findings in the latest studies, wogonin shows a wide range of antitumor effects, with the characteristics of multi-pathway, multi-link and multi-target, such as promoting tumor cell apoptosis through ROS or Ca(2+)-mediated signal paths, enhancing tumor cytotoxicity by TNF-α and TRAIL, blocking tumor cell cycle, inhibiting tumor angiogenesis and resisting cancer synergistically with chemotherapeutic drugs. Moreover, Wogonin could enhance body immune function by enhancing immune cell infiltration, regulating the immune cell phenotype and promoting relevant cytokine secretion. In this paper, the authors summarized the advance in studies on wogonin's antitumor and immunomodulatory effects.

• Authors: Wei-Ming Xiao, Ping Bu, Wei-Juan Gong
• Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (Zhongguo Zhong Yao Za Zhi) Vol. 39 Issue 16 Pg. 3004-9 (Aug 2014) ISSN: 1001-5302 [Print] China
• PMID: 25509278 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Antineoplastic Agents
• Drugs, Chinese Herbal
• Flavanones
• Immunologic Factors
• Tumor Necrosis Factor-alpha
• wogonin

Topics

• Animals
• Antineoplastic Agents (therapeutic use)
• Apoptosis (drug effects)
• Drugs, Chinese Herbal (therapeutic use)
• Flavanones (therapeutic use)
• Humans
• Immunologic Factors (therapeutic use)
• Neoplasms (drug therapy, immunology, physiopathology)
• Tumor Necrosis Factor-alpha (genetics, immunology)