A free-blockage controlled release system based on the hydrophobic/hydrophilic conversion of mesoporous silica nanopores.

Abstract

A pH-responsive free-blockage release system was achieved through controlling the hydrophobic/hydrophilic conversion of mesoporous silica nanopores. This system further presented pulsatile release with changing pH values between 4.0 and 7.0 for several cycles. This free-blockage release system could also release antitumor agents to induce cell death after infecting tumor cells and could have the ability of continuous infection to tumor cells with high drug-delivery efficiency and few side effects.

• Authors: Wenqian Wang, Linfeng Chen, Li-Ping Xu, Hongwu Du, Yongqiang Wen, Yanlin Song, Xueji Zhang
• Journal: Chemistry (Weinheim an der Bergstrasse, Germany) (Chemistry) Vol. 21 Issue 6 Pg. 2680-5 (Feb 02 2015) ISSN: 1521-3765 [Electronic] Germany
• PMID: 25504676 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Chemical References

• Antineoplastic Agents
• Delayed-Action Preparations
• Drug Carriers
• Epirubicin
• Silicon Dioxide

Topics

• Antineoplastic Agents (chemistry, toxicity)
• Cell Survival (drug effects)
• Delayed-Action Preparations
• Drug Carriers (chemistry)
• Epirubicin (chemistry, toxicity)
• HeLa Cells
• Humans
• Hydrogen-Ion Concentration
• Hydrophobic and Hydrophilic Interactions
• Nanoparticles (chemistry)
• Nanopores
• Porosity
• Silicon Dioxide (chemistry)