Mucolipidosis type IV protein TRPML1-dependent lysosome formation.

Abstract

Lysosomes are dynamic organelles that undergo cycles of fusion and fission with themselves and with other organelles. Following fusion with late endosomes to form hybrid organelles, lysosomes are reformed as discrete organelles. This lysosome reformation or formation is a poorly understood process that has not been systematically analyzed and that lacks known regulators. In this study, we quantitatively define the multiple steps of lysosome formation and identify the first regulator of this process.

• Authors: Austin Miller, Jessica Schafer, Cameron Upchurch, Ellen Spooner, Julie Huynh, Sebastian Hernandez, Brooke McLaughlin, Liam Oden, Hanna Fares
• Journal: Traffic (Copenhagen, Denmark) (Traffic) Vol. 16 Issue 3 Pg. 284-97 (Mar 2015) ISSN: 1600-0854 [Electronic] England
• PMID: 25491304 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)
• Copyright: © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Chemical References

• Mcoln1 protein, mouse
• Transient Receptor Potential Channels

Topics

• Animals
• Bone Marrow (metabolism, pathology)
• Cell Line
• Endosomes (metabolism, physiology)
• Lysosomes (metabolism, physiology)
• Mice
• Transient Receptor Potential Channels (metabolism)