Endoscopic endonasal resection of skull base meningiomas: the significance of a "cortical cuff" and brain edema compared with careful case selection and surgical experience in predicting morbidity and extent of resection.

Abstract

OBJECT:

This paper describes a consecutive series of skull base meningiomas resected using an endoscopic endonasal approach through various corridors at a single institution over 7 years. The impact of case selection and experience, the presence of a cortical cuff between the tumor and surrounding vessels, and brain edema on morbidity and rates of gross-total resection (GTR) were examined.

METHODS:

A retrospective review of a series of 46 skull base meningiomas from a prospective database was conducted. The series of cases were divided by location: olfactory groove (n = 15), tuberculum and planum (n = 20), sellar/cavernous (n = 9) and petroclival (n = 2). Gross-total resection was never intended in the sellar/cavernous tumors, which generally invaded the cavernous sinus. Clinical charts, volumetric imaging, and pathology were reviewed to assess the extent of resection and complications. Cases were divided based on a time point in which surgical technique and case selection improved into Group 1 (surgery prior to June 2008; n = 21) and Group 2 (surgery after June 2008; n = 25) and into those with and without a cortical cuff and with and without brain edema.

RESULTS:

Improved case selection had the greatest impact on extent of resection. For the entire cohort, rates of GTR went from 38% to 76% (p = 0.02), and for cases in which GTR was the intent, the rates went from 63% to 84% (not significant), which was mostly driven by the planum and tuberculum meningiomas, which went from 75% to 91.7 % (nonsignificant difference). The presence of a cortical cuff and brain edema had no impact on outcomes. There were 3 CSF leaks (6.5%) but all were in Group 1. Hence, CSF leak improved from 14.2% to 0% with surgical experience. Lessons learned for optimal case selection are discussed.

CONCLUSIONS:

Surgical outcome for endonasal endoscopic resection of skull base meningiomas depends mostly on careful case selection and surgical experience. Imaging criteria such as the presence of a cortical cuff or brain edema are less important.

• Authors: Osaama H Khan, Vijay K Anand, Theodore H Schwartz
• Journal: Neurosurgical focus (Neurosurg Focus) Vol. 37 Issue 4 Pg. E7 ( 2014) ISSN: 1092-0684 [Electronic] United States
• PMID: 25465040 (Publication Type: Journal Article)

Topics

• Adult
• Brain Edema (surgery)
• Endoscopy (methods)
• Female
• Humans
• Magnetic Resonance Imaging
• Male
• Meningeal Neoplasms (surgery)
• Meningioma (surgery)
• Middle Aged
• Morbidity
• Nasal Cavity (surgery)
• Nose (surgery)
• Postoperative Complications (mortality, physiopathology)
• Predictive Value of Tests
• Retrospective Studies
• Skull Base (surgery)
• Treatment Outcome
• Young Adult