Antidepressant agents in short bowel syndrome.

Abstract

PURPOSE:

This study aimed to determine whether short small intestine modifies antidepressant concentrations.

METHODS:

The Css values and concentration-dose ratios (CDRs) of citalopram or escitalopram, administered orally or intravenously, were determined in patients with short bowel syndrome.

FINDINGS:

Eight patients (6 males and 2 females) were included in the study. High CDRs were obtained in orally treated patients with >180 cm of small bowel and in those with >80 cm of small bowel and 50% of colon. Three patients had low Css values, including 1 patient who received intravenous treatment.

IMPLICATIONS:

The variability of drug absorption and metabolism makes prescribing SSRIs challenging in these patients.

• Authors: Elodie Faye, Olivier Corcos, Frédérique Lancelin, Xavier Declèves, Jean-François Bergmann, Francisca Joly, Célia Lloret-Linares
• Journal: Clinical therapeutics (Clin Ther) Vol. 36 Issue 12 Pg. 2029-2033.e3 (Dec 01 2014) ISSN: 1879-114X [Electronic] United States
• PMID: 25450472 (Publication Type: Journal Article)
• Copyright: Copyright © 2014 Elsevier HS Journals, Inc. All rights reserved.

Chemical References

• Antidepressive Agents
• Serotonin Uptake Inhibitors
• Citalopram

Topics

• Adult
• Aged
• Antidepressive Agents (pharmacokinetics, therapeutic use)
• Citalopram (pharmacokinetics, therapeutic use)
• Depressive Disorder (complications, drug therapy, metabolism)
• Female
• Humans
• Male
• Middle Aged
• Selective Serotonin Reuptake Inhibitors (pharmacokinetics, therapeutic use)
• Short Bowel Syndrome (complications, metabolism)