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Short Bowel Syndrome

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A malabsorption syndrome resulting from extensive operative resection of the SMALL INTESTINE, the absorptive region of the GASTROINTESTINAL TRACT.

Also Known As:

Bowel Syndrome, Short; Bowel Syndromes, Short; Short Bowel Syndromes; Syndrome, Short Bowel; Syndromes, Short Bowel

Networked: 1156 relevant articles (73 outcomes, 111 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Diarrhea
2.	Weight Gain
3.	Crohn Disease (Crohn's Disease)
4.	Neoplasms (Cancer)
5.	Cholestasis

Experts

1.	Sukhotnik, Igor: 21 articles (12/2012 - 09/2002)
2.	Coran, Arnold G: 18 articles (12/2012 - 09/2002)
3.	Wales, Paul W: 13 articles (10/2014 - 09/2004)
4.	Messing, Bernard: 12 articles (09/2014 - 02/2003)
5.	Joly, Francisca: 11 articles (01/2015 - 03/2009)
6.	Ziegler, Thomas R: 11 articles (09/2011 - 11/2004)
7.	Jeppesen, Palle B: 10 articles (02/2015 - 01/2006)
8.	Steiger, Ezra: 10 articles (05/2014 - 06/2003)
9.	Jeppesen, P B: 10 articles (10/2013 - 09/2005)
10.	Buchman, Alan L: 10 articles (12/2012 - 07/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Short Bowel Syndrome:

1.	Growth Hormone (Somatotropin)IBA 06/01/2011 - "The purpose of this systematic review was to assess the efficacy of growth hormone (GH) treatment in patients with short bowel syndrome (SBS). " 08/01/2000 - "To investigate the effect of growth hormone on proliferative activity of the residual small intestinal mucosa after massive small intestinal resection and to evaluate the clinical efficacy of bowel rehabilitative therapy for short bowel syndrome. " 06/01/2011 - "Growth hormone for intestinal adaptation in patients with short bowel syndrome: systematic review and meta-analysis of randomized controlled trials." 11/01/2011 - "Growth hormone to improve short bowel syndrome intestinal autonomy: a pediatric randomized open-label clinical trial." 11/01/2006 - "Growth hormone favorably affects bone turnover and bone mineral density in patients with short bowel syndrome undergoing intestinal rehabilitation."
2.	Glutamine (L-Glutamine)FDA Link 08/01/1994 - "Glutamine metabolism in children with short-bowel syndrome: a stable isotope study." 01/01/2012 - "Our results showed that honey/glutamine combination had comparative therapeutic advantage over glutamine or honey and may be a preferred treatment for short bowel syndrome patients." 09/01/2010 - "The effects of oral liquid and intravenous glutamine on bowel adaptation in a rabbit short bowel syndrome model." 08/01/2002 - "Glutamine for short-bowel syndrome." 08/01/2001 - "Effect of glutamine in short-bowel syndrome."
3.	Octreotide (Sandostatin)FDA LinkGeneric 05/01/2001 - "The aim of this study was to assess the effects of the long-acting release (LAR) depot octreotide preparation Sandostatin LAR Depot on stool water and electrolyte losses, fecal fat excretion, and GI transit in patients with short bowel syndrome. " 05/01/2001 - "An open trial of octreotide long-acting release in the management of short bowel syndrome." 03/01/1998 - "This study was conducted to determine whether octreotide inhibits intestinal adaptation in a rat model of short bowel syndrome. " 01/01/1994 - "Several clinical studies in patients with short bowel syndrome have reported a reduction of intestinal output in patients taking octreotide compared with controls. " 09/01/2002 - "Because of its antisecretory properties, sandostatin has been advocated for the treatment of patients with short bowel syndrome (SBS). "
4.	teduglutideIBA 09/01/2009 - "In the treatment of short bowel syndrome, GLP-2 and the long-acting GLP-2 analogue teduglutide (Gattex) are effective in improving fluid absorption. " 07/01/2013 - "For patients with short-bowel syndrome intestinal failure, the efficacy of teduglutide was maintained over 52 weeks and the safety profile was sufficient for it to be considered for long-term use. " 06/01/2008 - "Based on the results of the few Phase II studies and the preliminary results of a Phase III trial, teduglutide at doses of 0.05 or 0.10 mg/kg/day may improve many clinical, laboratory and histologic abnormalities in short bowel syndrome patients. " 05/01/2015 - "Teduglutide: a guide to its use in short bowel syndrome." 12/01/2014 - "Teduglutide is a recombinant analogue of human glucagonlike peptide-2 (GLP-2) that was recently approved by the US and European regulatory agencies FDA and EMA for the treatment of short bowel syndrome (SBS). "
5.	Glucagon-Like Peptide 2IBA 01/01/2009 - "In a short-term study, Glucagon-like peptide 2 (GLP-2) has been shown to improve intestinal absorption in short bowel syndrome (SBS) patients. " 01/01/2009 - "Glucagon-like peptide 2 (GLP-2) has been shown to improve intestinal absorption in short bowel syndrome (SBS) patients in a short-term study. " 06/01/2014 - "The intestinotrophic factor glucagon-like peptide 2 (GLP-2) improves gut function in adult patients with short bowel syndrome, but its effect in pediatric patients remains unknown. " 10/01/2013 - "Glucagon-like peptide 2 (GLP-2) decreases gastric and intestinal motility, reduces gastric secretions, promotes intestinal growth and improves post-resection structural and functional adaptation in short bowel syndrome (SBS). " 11/01/2006 - "Synergistic effect of supplemental enteral nutrients and exogenous glucagon-like peptide 2 on intestinal adaptation in a rat model of short bowel syndrome."
6.	Somatostatin (Somatotropin Release-Inhibiting Factor)IBA 06/01/1996 - "Somatostatin (SMS) is administered to patients with short bowel syndrome and enterocutaneous fistulae. " 01/01/1990 - "Short bowel syndrome and somatostatin 201-995." 12/01/1982 - "Somatostatin decreases diarrhea in patients with the short-bowel syndrome." 05/01/1987 - "We report the efficacy of a long-acting somatostatin analogue, associated with conventional therapy, in controlling profuse ileostomy losses in a child with short bowel syndrome following a volvulus. " 07/01/1989 - "The effect of a long acting somatostatin analogue SMS 201-995 on stomal effluents in patients with severe short bowel syndrome was investigated in a double blind placebo controlled balance study. "
7.	Human Growth Hormone (Saizen)FDA LinkGeneric 10/01/2006 - "This study evaluates the economic impact of somatropin use in the management of short bowel syndrome. " 05/01/2006 - "Treatment of adult short bowel syndrome with recombinant human growth hormone: a review of clinical studies." 06/01/1998 - "In this study we investigated the effect of low-dose recombinant human growth hormone over eight weeks on nasal congestion as measured by nasal peak flow in a randomized, placebo-controlled, double-blind crossover clinical trial in ten patients with short bowel syndrome. " 09/01/2010 - "This prospective study aimed to establish the effect of recombinant human growth hormone (rhGH) on intestinal function in children with short bowel syndrome (SBS). " 09/01/2010 - "Effect of recombinant human growth hormone on intestinal absorption and body composition in children with short bowel syndrome."
8.	Glucagon (Glukagon)FDA Link 01/01/2008 - "The objective of the present study was to examine the effect of glucagon-like peptide-2 (GLP-2) administration in a piglet, juvenile model of short bowel syndrome. " 10/01/2014 - "Endogenous glucagon-like peptide-2 (GLP-2) levels and intestinal adaptation are reduced in distal-intestinal resection animal models of short bowel syndrome (SBS) that lack remnant ileum. " 10/01/2014 - "Exogenous glucagon-like peptide-2 improves outcomes of intestinal adaptation in a distal-intestinal resection neonatal piglet model of short bowel syndrome." 06/10/2013 - "Acute effects of continuous infusions of glucagon-like peptide (GLP)-1, GLP-2 and the combination (GLP-1+GLP-2) on intestinal absorption in short bowel syndrome (SBS) patients. " 06/01/2013 - "Role of glucagon-like peptide-2 deficiency in neonatal short-bowel syndrome using neonatal piglets."
9.	Glucose (Dextrose)FDA LinkGeneric 11/17/1998 - "The hyperplastic mucosa in the experimental short bowel syndrome exhibits unchanged epithelial barrier properties and a differential functional adaptation with a 150% increase in Na-glucose cotransport but no change in electroneutral NaCl cotransport. " 01/01/1990 - "We conclude that the mucosa in the short bowel syndrome is characterized by an increase in glucose-dependent electrogenic Na absorption, probably as an adaptive response to the reduced overall absorptive area of the remaining intestine." 01/01/1989 - "[Short bowel syndrome and glucose tolerance]." 10/01/1978 - "An oral glucose and electrolyte solution (glucose 120 mmole/liter, Na 100 mEq/liter K 10 mEq/liter, Cl 70 mEq/liter, HCO3 40mEq/liter) was used successfully in a patient with the short bowel syndrome. " 10/07/1972 - "Failure of oral glucose therapy in short-bowel syndrome."
10.	SodiumIBA 04/01/2001 - "Effect of administration of Lactobacillus casei shirota on sodium balance in an infant with short bowel syndrome." 03/01/1991 - "Isotonic high-sodium oral rehydration solution for increasing sodium absorption in patients with short-bowel syndrome." 02/01/1989 - "Energy absorption from a liquid test meal, intestinal transit rate and water and sodium output over a six hour period were measured in five patients with an ileostomy and 12 patients with the short bowel syndrome, five of whom were on longterm parenteral nutrition. " 07/01/2002 - "Transfection of the sodium/glucose cotransporter into colon mucosa: a novel treatment for short bowel syndrome." 03/01/1991 - "We conclude that replacement of glucose with maltodextrins and addition of sodium in the standard oral rehydration solution results in improved sodium absorption in short-bowel syndrome."

Therapies and Procedures

1.	Parenteral Nutrition 01/01/2000 - "At this moment, however, long-term parenteral nutrition is still the first-line treatment of the short-bowel syndrome world-wide because of the excellent results with regard to patient survival. " 02/01/1998 - "An amino acid-based complete infant formula improved feeding tolerance and eliminated the need for parenteral nutrition in four children with short bowel syndrome who had previously required long-term parenteral nutrition. " 07/01/2014 - "The introduction of hepatoprotective strategies and multidisciplinary management has significantly improved the outcome of neonates with short bowel syndrome (SBS) who require parenteral nutrition (PN). " 01/01/2011 - "The consequences of ECF include short bowel syndrome and the need for long term parenteral nutrition.ECF can heal spontaneously and in the case of IBD can be cured by medical therapy in some instances. " 02/01/2010 - "Children with surgical short bowel syndrome also face an improved outcome because of improvements in the composition of parenteral nutrition (TPN) and in enteral alimentation strategies. "
2.	Transplantation (Transplant Recipients) 07/01/2014 - "Intestinal transplantation is the most effective treatment for patients with short bowel syndrome and small bowel insufficiencies. " 12/01/2005 - "Early living related small intestine transplantation is a good treatment for short bowel syndrome." 06/01/2012 - "Intestinal transplantation (ITx) and multivisceral transplantation (MVTx) has evolved into a viable treatment option for short bowel syndrome and intestinal failure due to a variety of factors including improved immunosuppressive regimens, superior surgical and medical management, and enhanced posttransplant monitoring. " 01/01/1998 - "Small bowel transplantation (SBT) has become an increasingly promising treatment for short bowel syndrome. " 06/01/2009 - "Multidisciplinary teams created to manage the complexities of this population have shown improved outcomes and the ability to prevent or slow progression of life-threatening complications that would otherwise lead to intestinal transplantation in a large number of patients with short bowel syndrome. "
3.	Total Parenteral Nutrition 12/01/2011 - "Short bowel syndrome (SBS) occurs in patients fed total parenteral nutrition (TPN) after massive intestinal resection. " 05/01/2011 - "GLP-2 has garnered interest as a therapeutic most notably by reducing reliance on total parenteral nutrition in patients with short bowel syndrome. " 01/01/2010 - "Dependence on total parenteral nutrition in intestinal failure or short bowel syndrome patients can lead to many complications. " 06/01/2009 - "Total parenteral nutrition in patients with short bowel syndrome." 01/01/2009 - "Altogether we had 30 patients needing total parenteral nutrition (TPN) in the last 5 years: 46% short bowel syndrome, 18% oesophageal disorders, 15% oncology patients, 21 % septicaemia and other disorders. "
4.	Drug Therapy (Chemotherapy) 08/01/1999 - "We report the case of a 40-yr-old woman with short bowel syndrome and depression requiring antidepressant drug therapy. " 08/01/1999 - "Oral drug therapy in patients with short bowel syndrome can be quite challenging. " 05/01/1998 - "Drug therapy in short bowel syndrome can be complicated by inadequate or incomplete absorption of drugs in the small intestine. " 05/01/2006 - "Guidelines for pharmacotherapy, nutritional management, and weaning parenteral nutrition in adult patients with short bowel syndrome: introduction." 01/01/1996 - "TPN-induced fulminant beriberi became evident 4-40 days after the initiation of TPN, and was more likely to develop in patients with malignancies, ulcerative colitis, and short bowel syndrome, as well as in those receiving chemotherapy. "
5.	Enteral Nutrition (Feeding, Tube) 02/01/2012 - "Serial transverse enteroplasty is a feasible and safe treatment for short bowel syndrome patients, which helps to improve enteral nutrition and promote growth. " 11/01/2014 - "Improved tolerance for enteral nutrition after serial transverse enteroplasty (STEP) in infants and children with short bowel syndrome--a seven-year single-center experience." 01/01/2014 - "Recycling of jejunal effluent to enable enteral nutrition in short bowel syndrome." 05/01/2013 - "This report emphasizes the importance of close monitoring for nutrient deficiencies during drug shortages and supplementing with oral or enteral nutrition when feasible, particularly in high-risk patients such as those with intestinal malabsorption or short bowel syndrome who are dependent on long-term PN." 04/01/2013 - "Neonatal short bowel syndrome as a model of intestinal failure: physiological background for enteral feeding."