Abstract |
Anti-PL-7 is an anti- tRNA synthetase antibody, and interstitial lung disease (ILD) is the most frequent complication of anti-PL-7-associated antisynthetase syndrome. However, the features of ILD have not been fully elucidated. The present study retrospectively compares 7 and 15 patients who were positive for anti-PL-7 and anti-Jo-1 antibodies, respectively. The features of ILD did not significantly differ between the two groups, but the ratio of lymphocytes in bronchoalveolar lavage fluid was higher in the Jo-1 than in the PL-7 group. High-resolution computed tomography revealed nonspecific interstitial pneumonia in all patients in the PL-7 group and organizing pneumonia in four of the 15 patients in the Jo-1 group. These findings suggest that pulmonary complications slightly differ between patients expressing anti-PL-7 and anti-Jo-1 antibodies. Further studies are required to clarify the features of ILD associated with PL-7.
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Authors | Masaomi Tomonaga, Noriho Sakamoto, Yuji Ishimatsu, Tomoyuki Kakugawa, Tatsuhiko Harada, Shota Nakashima, Atsuko Hara, Shintaro Hara, Yoshihiro Horai, Atsushi Kawakami, Hiroshi Mukae, Shigeru Kohno |
Journal | Lung
(Lung)
Vol. 193
Issue 1
Pg. 79-83
(Feb 2015)
ISSN: 1432-1750 [Electronic] United States |
PMID | 25394672
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Antibodies, Antinuclear
- Biomarkers
- Jo-1 antibody
- Threonine-tRNA Ligase
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Topics |
- Adult
- Antibodies, Antinuclear
(blood)
- Biomarkers
(blood)
- Cryptogenic Organizing Pneumonia
(blood, diagnosis, etiology, immunology)
- Female
- Humans
- Lung
(diagnostic imaging)
- Lung Diseases, Interstitial
(blood, diagnosis, etiology, immunology)
- Male
- Middle Aged
- Myositis
(blood, complications, diagnosis, immunology)
- Predictive Value of Tests
- Retrospective Studies
- Threonine-tRNA Ligase
(immunology)
- Tomography, X-Ray Computed
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