Randomized, controlled trial of Interpersonal and Social Rhythm Therapy for young people with bipolar disorder.

Abstract

OBJECTIVE:

This randomized, controlled clinical trial compared the effect of interpersonal and social rhythm therapy (IPSRT) to that of specialist supportive care (SSC) on depressive outcomes (primary), social functioning, and mania outcomes over 26-78 weeks in young people with bipolar disorder receiving psychopharmacological treatment.

METHODS:

Subjects were aged 15-36 years, recruited from a range of sources, and the patient groups included bipolar I disorder, bipolar II disorder, and bipolar disorder not otherwise specified. Exclusion criteria were minimal. Outcome measures were the Longitudinal Interval Follow-up Evaluation and the Social Adjustment Scale. Paired-sample t-tests were used to determine the significance of change from baseline to outcome period. Analyses of covariance were used to determine the impact of therapy, impact of lifetime and current comorbidity, interaction between comorbidity and therapy, and impact of age at study entry on depression.

RESULTS:

A group of 100 participants were randomized to IPSRT (n = 49) or SSC (n = 51). The majority had bipolar I disorder (78%) and were female (76%), with high levels of comorbidity. After treatment, both groups had improved depressive symptoms, social functioning, and manic symptoms. Contrary to our hypothesis, there was no significant difference between therapies. There was no impact of lifetime or current Axis I comorbidity or age at study entry. There was a relative impact of SSC for patients with current substance use disorder.

CONCLUSIONS:

IPSRT and SSC used as an adjunct to pharmacotherapy appear to be effective in reducing depressive and manic symptoms and improving social functioning in adolescents and young adults with bipolar disorder and high rates of comorbidity. Identifying effective treatments that particularly address depressive symptoms is important in reducing the burden of bipolar disorder.

• Authors: Maree L Inder, Marie T Crowe, Suzanne E Luty, Janet D Carter, Stephanie Moor, Christopher M Frampton, Peter R Joyce
• Journal: Bipolar disorders (Bipolar Disord) Vol. 17 Issue 2 Pg. 128-38 (Mar 2015) ISSN: 1399-5618 [Electronic] Denmark
• PMID: 25346391 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
• Copyright: © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Chemical References

• Antimanic Agents

Topics

• Adolescent
• Adult
• Antimanic Agents (therapeutic use)
• Bipolar Disorder (psychology, therapy)
• Combined Modality Therapy
• Depression (psychology, therapy)
• Female
• Humans
• Interpersonal Relations
• Male
• Psychotherapy (methods)
• Social Adjustment
• Substance-Related Disorders (psychology)
• Treatment Outcome
• Young Adult