SNP 1772 C > T of HIF-1α gene associates with breast cancer risk in a Taiwanese population.

Abstract

BACKGROUND:

Hypoxia inducible factor 1α (HIF-1α) is a stress-responsive transcription factor to hypoxia and its expression is correlated to tumor progression and angiogenesis. Several single nucleotide polymorphisms (SNPs) of HIF-1α gene in the oxygen-dependent degradation (ODD) domain was reportedly associated with increased HIF-1α activity.

RESULTS:

In this study, we focused on the relationship between SNP 1772 C > T (rs11549465) of HIF-1α gene and its breast cancer risk, as well as its correlation with HIF-1α expression and tumor angiogenesis. Ninety six breast cancer patients and 120 age-matched controls were enrolled. We found that 1772 T allele of HIF-1α gene was associated with increased breast cancer risk (adjusted OR = 14.51; 95% CI: 6.74-31.24). This SNP was not associated with clinicopathologic features of angiogenesis such as VEGF activity and the micro-vessel density and survival of breast cancer patients.

CONCLUSION:

Taken together, the 1772 C > T of HIF-1α gene is a potential biomarker for breast cancer susceptibility.

• Authors: Chih-Jen Huang, Shi-Long Lian, Ming-Feng Hou, Chee-Yin Chai, Yi-Hsing Yang, Sheng-Fung Lin, Hsueh-Wei Chang
• Journal: Cancer cell international (Cancer Cell Int) Vol. 14 Issue 1 Pg. 87 ( 2014) ISSN: 1475-2867 [Print] England
• PMID: 25302049 (Publication Type: Journal Article)