Abstract | BACKGROUND AND OBJECTIVE:
Persistent organic pollutants (POPs) are stable organic compounds generated through different industrial activities. Liver is involved in the metabolism of POPs, and hence exposure to POPs may interfere with liver function. Although a few studies have shown adverse effects of POPs on liver function, large-scale studies involving humans are lacking. We performed this large population-based cross-sectional study to assess the associations between different POPs and liver dysfunction biomarkers. METHODS: RESULTS: The mono-ortho PCB TEQ values were found to be significantly positively associated with bilirubin (β=0.71, P=0.008), while sum of OC pesticide concentrations was negatively associated with ALP (β=-0.02, P=0.002) after adjusting for various potential confounders. When analyzed individually, a number of different POPs were associated with ALP, ALT and bilirubin. No such association with GGT was observed. CONCLUSION:
|
Authors | Jitender Kumar, Lars Lind, Samira Salihovic, Bert van Bavel, Erik Ingelsson, P Monica Lind |
Journal | Environmental research
(Environ Res)
Vol. 134
Pg. 251-6
(Oct 2014)
ISSN: 1096-0953 [Electronic] Netherlands |
PMID | 25173059
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Copyright | Copyright © 2014 Elsevier Inc. All rights reserved. |
Chemical References |
- Biomarkers
- Environmental Pollutants
- Organic Chemicals
|
Topics |
- Aged
- Biomarkers
(blood)
- Environmental Pollutants
(toxicity)
- Female
- Humans
- Liver
(drug effects, physiopathology)
- Liver Function Tests
- Male
- Organic Chemicals
(toxicity)
- Prospective Studies
- Sweden
|